787544-61-0

Basic information

• Product Name: (R)-3-AMINO-3-(3-NITRO-PHENYL)-PROPIONIC ACID
• Synonyms: RARECHEM DF HC P253;(R)-BETA-(3-NITROPHENYL)ALANINE;(R)-3-AMINO-3-(3-NITROPHENYL)PROPANOIC ACID;(R)-3-AMINO-3-(3-NITRO-PHENYL)-PROPIONIC ACID;L-BETA-HOMO(3-NITROPHENYL)GLYCINE;H-PHG(3-NO2)-(C*CH2)OH;H-D-BETA-PHE(3-NO2)-OH;(R)-3-(3-NITROPHENYL)-BETA-ALANINE
• CAS NO: 787544-61-0
• Molecular Formula: C₉H₁₀N₂O₄
• Molecular Weight: 210.19
• EINECS: 200-528-9
• Product Categories: 3-Amino-3-phenylpropanoic Acid Analogs;API intermediates;B-Amino
• Mol File: 787544-61-0.mol

Chemical Properties

• Boiling Point: 384.5 °C at 760 mmHg
• Flash Point: 186.4 °C
• Appearance: /
• Density: 1.404 g/cm³
• Vapor Pressure: 1.34E-06mmHg at 25°C
• Refractive Index: 1.612
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: (R)-3-AMINO-3-(3-NITRO-PHENYL)-PROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-AMINO-3-(3-NITRO-PHENYL)-PROPIONIC ACID(787544-61-0)
• EPA Substance Registry System: (R)-3-AMINO-3-(3-NITRO-PHENYL)-PROPIONIC ACID(787544-61-0)

Safety Data

• Hazardous Substances Data: 787544-61-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(R)-3-AMINO-3-(3-NITRO-PHENYL)-PROPIONIC ACID is used as a potential pharmaceutical agent for its possible biological activity. It may contribute to the development of new drugs or serve as a key intermediate in the synthesis of therapeutically relevant compounds.
Used in Chemical Synthesis:
In the field of organic chemistry, (R)-3-AMINO-3-(3-NITRO-PHENYL)-PROPIONIC ACID is used as a building block for the synthesis of other complex organic molecules. Its unique functional groups allow for various chemical reactions, facilitating the creation of a wide range of chemical entities with diverse applications.
Used in Research and Development:
(R)-3-AMINO-3-(3-NITRO-PHENYL)-PROPIONIC ACID is utilized in research settings to explore its chemical properties, reactivity, and potential interactions with biological systems. This helps in understanding its role in chemical and biological processes, which can further guide its application in various industries.

InChI:InChI=1/C9H10N2O4/c10-8(5-9(12)13)6-2-1-3-7(4-6)11(14)15/h1-4,8H,5,10H2,(H,12,13)/t8-/m1/s1

Upstream product

• 5678-47-7 3-amino-3-(3-nitro-phenyl)-propionic acid 

Downstream Products

• 499995-72-1 (R)-3-amino-3-(3-nitrophenyl)propanoic acid hydrochloride 
• 918810-80-7 (R)-ethyl 3-(3-aminophenyl)-3-(tert-butoxycarbonylamino)propanoate 

Relevant articles and documents

Kinetic Resolution of Aromatic β-Amino Acids Using a Combination of Phenylalanine Ammonia Lyase and Aminomutase Biocatalysts

An enzymatic strategy for the preparation of (R)-β-arylalanines employing phenylalanine aminomutase and ammonia lyase (PAM and PAL) enzymes has been demonstrated. Candidate PAMs with the desired (S)-selectivity from Streptomyces maritimus (EncP) and Bacillus sp. (PabH) were identified via sequence analysis using a well-studied template sequence. The newly discovered PabH could be linked to the first ever proposed biosynthesis of pyloricidin-like secondary metabolites and was shown to display better β-lyase activity in many cases. In spite of this, a method combining the higher conversion of EncP with a strict α-lyase from Anabaena variabilis (AvPAL) was found to be more amenable, allowing kinetic resolution of five racemic substrates and a preparative-scale reaction with >98% (R) enantiomeric excess. This work represents an improved and enantiocomplementary method to existing biocatalytic strategies, allowing simple product separation and modular telescopic combination with a preceding chemical step using an achiral aldehyde as starting material. (Figure presented.).

β-alanine derivatives

The invention relates to β-alanine derivatives of formula (I), wherein Q1, Q2, Q3, Q4, R1, R2, R3, R4, R5, R6and n have the meaning as disclosed