787608-48-4Relevant academic research and scientific papers
Novel pyrazinone inhibitors of mast cell tryptase: Synthesis and SAR evaluation
Hopkins, Corey,Neuenschwander, Kent,Scotese, Anthony,Jackson, Sharon,Nieduzak, Thaddeus,Pauls, Henry,Liang, Guyan,Sides, Keith,Cramer, Dona,Cairns, Jennifer,Maignan, Sebastien,Mathieu, Magali
, p. 4819 - 4823 (2007/10/03)
In this manuscript, the synthesis and SAR evaluation of a novel pyrazinone class of tryptase inhibitors is described. Chemical optimization of the P1 and P4 groups led to the identification of 7p (Ki = 93 nM) as a potent inhibitor of mast cell tryptase.
