787617-89-4

Upstream product

• 61350-60-5 (S)-benzyloxycarbonyl-proline acid chloride 
• 127940-39-0 (R)-4-{[(E)-4-Methoxy-phenylimino]-methyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 

Downstream Products

• 787617-97-4 (-)-(3R,4S)-5-benzyloxycarbonyl-2-(tert-butoxycarbonyl)-3-[(R)-3-tert-butoxycarbonyl-2,2-dimethyl-1,3-oxazolidin-4-yl]-2,5-diazaspiro[3.4]octan-1-one 
• 787617-93-0 (+)-(3R,4S)-5-benzyloxycarbonyl-3-[(R)-3-tert-butoxycarbonyl-2,2-dimethyl-1,3-oxazolidin-4-yl]-2,5-diazaspiro[3.4]octan-1-one 
• 1053605-89-2 (1R,4S)-1-((R)-1-Amino-2-hydroxy-ethyl)-2-(4-methoxy-phenyl)-3-oxo-2,5-diaza-spiro[3.4]octane-5-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Diastereoselective [2+2]-cycloaddition reactions of unsymmetrical cyclic ketenes with imines: Synthesis of modified prolines and theoretical study of the reaction mechanism

The synthesis of enantiomerically pure modified proline derivatives was achieved by using spiro β-lactams as starting material that were prepared in turn by the [2+2]-cycloaddition of unsymmetrical cyclic ketenes with optically active imines. A theoretica