787617-95-2

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 787618-10-4 (3R,4S,7R)-7-(tert-Butyl-dimethyl-silanyloxy)-1-oxo-3-phenyl-2,5-diaza-spiro[3.4]octane-5-carboxylic acid benzyl ester 
• 787617-84-9 (-)-(3R,4S,7R)-5-benzyloxycarbonyl-7-(tert-butyldimethylsilyloxy)-2-(4-methoxyphenyl)-3-phenyl-2,5-diazaspiro[3.4]octan-1-one 
• 1613-90-7 4-methoxy-N-[(E)-phenylmethylidene]aniline 

Downstream Products

• 787617-98-5 methyl (-)-(2S,3R)-2-[(R)-1-benzyloxycarbonyl-4-(tert-butyldimethylsilyloxy)pyrrolidin-2-yl]-3-(N-tert-butoxycarbonylamino)propanoate 
• 1053627-48-7 (2S,4R)-2-((R)-Amino-phenyl-methyl)-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 

Relevant academic research and scientific papers

Diastereoselective [2+2]-cycloaddition reactions of unsymmetrical cyclic ketenes with imines: Synthesis of modified prolines and theoretical study of the reaction mechanism

The synthesis of enantiomerically pure modified proline derivatives was achieved by using spiro β-lactams as starting material that were prepared in turn by the [2+2]-cycloaddition of unsymmetrical cyclic ketenes with optically active imines. A theoretica