78771-13-8

Usage

Uses

Sarmazenil is a benzodiazepine receptor antagonist.

InChI:InChI=1/C15H14ClN3O3/c1-3-22-15(21)13-11-7-18(2)14(20)12-9(16)5-4-6-10(12)19(11)8-17-13/h4-6,8H,3,7H2,1-2H3

Upstream product

• 3400-09-7 dichloroamine 
• 78755-99-4 3,4-dihydro-4-methyl-6-chloro-2H-1,4-benzodiazepine-2,5(1H)-dione 
• 99-97-8 Dimethyl-p-toluidine 

Downstream Products

• 172407-34-0 7-chloro-3-(5-dibutylaminomethyl-1,3,4-oxadiazol-2-yl)-5-methyl-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one 
• 122384-14-9 L-663581 

Relevant academic research and scientific papers

Imidazodiazepine derivative

The present invention relates to compound 7-Chloro-3-(5-dimethylaminomethyl-[1,2,4]oxadiazol-3-yl)-5-methyl-4,5-dihydro-imidazo[1,5-a][1,4]benzodiazepin-6-one (I) and to the use of the compound of formula I for the manufacture of medicaments to be used as anxiolytic and/or anticonvulsant and/or non-sedative sleep-inducing medicaments.

Method of making diazepine derivatives

The present invention relates to a process for manufacturing diazepine derivatives of the general formula I wherein R1is lower alkyl and R2is hydrogen, or R1and R2are together —(CH2)n— and n is 2 or 3; R3is halogen, lower alkyl, lower alkoxy and m is 0, 1 or 2; R4is hydrogen or lower alkyl. The compounds of general formula I are valuable intermediate products for the manufacture of imidazo [1,5-a][1,4]diazepine derivatives, like for instance 7-chloro-3-(5-dimethylaminomethyl-[1,2,4]oxadiazol-3-yl)-5-methyl-4,5-dihydro-imidazo[1,5-a][1,4]benzodiazepin-6-one, which diazepine derivatives show excellent psychopharmacological properties as agonists of the central benzodiazepine receptors.