78775-63-0

Basic information

• Product Name: diethyl (2-phenylpropan-2-yl)propanedioate
• CAS NO: 78775-63-0
• Molecular Formula: C₁₆H₂₂O₄
• Molecular Weight: 278.3435
• Mol File: 78775-63-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 346°C at 760 mmHg
• Flash Point: 162.4°C
• Density: 1.06g/cm³
• Vapor Pressure: 5.92E-05mmHg at 25°C
• Refractive Index: 1.49
• CAS DataBase Reference: diethyl (2-phenylpropan-2-yl)propanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl (2-phenylpropan-2-yl)propanedioate(78775-63-0)
• EPA Substance Registry System: diethyl (2-phenylpropan-2-yl)propanedioate(78775-63-0)

Safety Data

• Hazardous Substances Data: 78775-63-0(Hazardous Substances Data)

Upstream product

• 6802-75-1 diethyl isopropylidenemalonate 
• 71478-47-2 phenylmanganese(II) chloride 
• 100-58-3 phenylmagnesium bromide 
• 60-29-7 diethyl ether 
• 71-43-2 benzene 

Downstream Products

• 1010-48-6 3-methyl-3-phenylbutanoic acid 
• 173067-74-8 5-(1-Methyl-1-phenyl-ethyl)-2-(4-nitro-phenoxy)-[1,3,2]dioxaphosphinane 2-oxide 
• 3910-35-8 1,1,3-trimethyl-3-phenylindane 
• 64287-40-7 <α,α-Dimethyl-benzyl>-carbaethoxy-keten 
• 78775-75-4 2-(α,α-Dimethylbenzyl)malonylchlorid 
• 149911-96-6 2-(Ethylmethylamino)-2,3-dimethyl-3-phenylbutansaeure-ethylester 
• 149911-95-5 2-(Ethylamino)-2,3-dimethyl-3-phenylbutansaeure-ethylester 
• 149912-04-9 2-Amino-2,3-dimethyl-3-phenylbutansaeure-ethylester 
• 116183-35-8 Morpholine-4-carboxylic acid {(R)-1-[(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-2-methyl-2-phenyl-propyl}-amide 
• 116183-34-7 (2S,3R,4S)-2-{[(4-morpholinylcarbonyl)-L-β,β-dimethylphenylalanyl-L-histidyl]amino}-1-cyclohexyl-3,4-dihydroxy-6-methylheptane 
• 114359-58-9 Ethyl 2(R,S)-[[(4-morpholinyl)carbonyl]amino]-3, 3-dimethyl-3-phenylpropionate 
• 114359-59-0 2(R,S)-[[(4-Morpholinyl)carbonyl]amino]-3,3-dimethyl-3-phenylpropionic acid 
• 173067-76-0 2-(1-Methyl-1-phenyl-ethyl)-propane-1,3-diol 
• 149912-03-8 Methyl(1-methyl-1-phenylethyl)malonsaeure-diethylester 

Relevant articles and documents

Antikoerper-katalysierte Hydrolyse von Phosphorsaeuretriestern

Keywords: Elektrostatische Wechselwirkungen, Katalytische Antikoerper, Phosphorsaeureester, Hydrolysen, Uebergangszustaende

Peptidylaminodiols

A renin inhibiting compound of the formula: STR1 wherein A is a substituent; W is C=O or CHOH; U is CH2 or NR2, provided that when W is CHOH then U is CH2 ; R1 is loweralkyl, cycloalkylmethyl, benzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, (4-imidazoyl)methyl, (alpha,alpha)-dimethylbenzyl, 1-benzyloxyethyl, phenethyl, phenoxy, thiophenoxy or anilino; R2 is hydrogen or loweralkyl; R3 is loweralkenyl, [(alkoxy)alkoxy]alkyl, (thioalkoxy)alkyl, lowerakenyl, benzyl or heterocyclic ring substituted methyl; R4 is loweralkyl, cycloalkylmethyl or benzyl; R5 is vinyl, formyl, hydroxymethyl or hydrogen; R7 is hydrogen or loweralkyl; R8 and R9 are independently selected from OH and NH2 ; and R6 is hydrogen, loweralkyl, vinyl or arylalkyl; provided that when R5 and R7 are both hydrogen and R8 and R9 are OH, the carbon bearing R5 is of the "R" configuration and the carbon bearing R6 is of the "S" configuration, or pharmaceutically acceptable salts or esters thereof. Also disclosed are renin inhibiting compositions, a method of treating hypertension, methods of making the renin inhibiting compounds and intermediates useful in making the renin inhibiting compounds.

ORGANOMANGANESE (II) REAGENTS XV. CONJUGATE ADDITION OF ORGANOMANGANESE REAGENTS TO ALKYLIDENEMALONIC ESTERS AND RELATED COMPOUNDS

Organomanganese reagents react with alkylidenemalonic esters or related compounds to give the conjugate addition products in good yields.Several examples illustrate the scope and the efficiency of this reaction.