78790-85-9Relevant academic research and scientific papers
Raf inhibitor compounds and methods of use thereof
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Page/Page column 40, (2010/11/26)
Compounds of Formula I are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
Chemoselective Reactions of 3-Chloroisonicotinonitrile
LaMattina, John L.,Taylor, Richard L.
, p. 4179 - 4182 (2007/10/02)
Chemoselective reactions of 3-chloroisonicotinonitrile (1) with nucleophiles are described.Treatment of 1 with sodium methoxide/methanol results in formation of the imino ether, which can be further elaborated into a triazole ring.However, when 1 is react
