78795-23-0Relevant academic research and scientific papers
Polymethylene derivatives of pyrimidine nucleic bases bearing ω-functional groups
Makinsky,Kritzyn,Uljanova,Zakharova,Nevinsky
, p. 662 - 668 (2007/10/03)
N1-Acyclic derivatives of pyrimidine bases (uracil, thymine, and cytosine) with hydrophobic polymethylene chains containing various functional groups in an ω-position of the alkyl substituent were synthesized. Their physicochemical properties and inhibitory effect on the HIV reverse transcriptase and human DNA topoisomerase I were studied.
Synthesis of new cytosine and thymine derivatives of potential immunomodulatory activity
Pini,Rossi,Stradi
, p. 779 - 794 (2007/10/03)
The synthesis and the main chemical and physical properties of some N1 alkylated cytosines and thymines are described.
5-ALKOXYMETHYL-1-HYDROXYALKYLURACILS WITH POTENTIAL ANTI-HIV ACTIVITY
Abdel-Megied, Ahmed E.-S.,Motawia, Mohammed S.,Pedersen, Erik B.,Nielsen, Carsten M.
, p. 713 - 722 (2007/10/02)
Acid catalyzed etherification of 5-hydroxymethyluracil (3) afforded the corresponding 5-alkoxymethyluracils (4a-h).Treatment of the sodium salt of compounds (4a-g) with 4-bromobutyl acetate afforded 1,3-bis-(4-acetyloxybutyl)- (5a-g) and 1-4-acetyloxybuty
Carbocyclic Analogs of Thymine Nucleosides and Related 1-Substituted Thymines
Shealy, Y.Fulmer,O'Dell, C.Allen,Thorpe, Martha C.
, p. 383 - 389 (2007/10/02)
The carbocyclic analogs of thymidine (IXf), 1-β-ribofuranosylthymine (IXg), and 1-β-3'-deoxyribofuranosylthymine (IXe) were synthesized by incorporating modifications into the Shaw method of synthesizing 2,4-(1H,3H)pyrimidinediones via acryloylureas.Simpler analogs of thymine nucleosides were also prepared by this method.The carbocyclic analog of thymidine displayed modest activity against Leukemia L1210 in vivo.It differs from a compound prepared previously by a Prins reaction.
