78797-02-1Relevant academic research and scientific papers
Allosteric deprogramming of a trinuclear heterometallic helicate
Riis-Johannessen,Harding, Lindsay P.,Jeffery, John. C.,Moon, Ryan,Rice, Craig R.
, p. 1577 - 1587 (2007)
Two multidentate ditopic ligands L1 and L2 which contain both N-donor and crown ether units have been synthesised. The potentially octadentate ligand L1 forms a trinuclear heterometallic double helicate with Cu(i) and Zn(ii) ([Zn2Cu(L1) 2]5+), whereas L2 forms a tetranuclear heterometallic double helicate with the same metal ions ([Zn2Cu 2(L2)2]6+). Both species have been characterised by 1H NMR, ESI-MS and single crystal X-ray crystallography. Reaction of [Zn2Cu2(L2) 2]6+ with Ba2+ results in the coordination of the crown ether units giving the simple barium coordinated species [Zn 2Cu2(L2)2Ba2] 10+. However, reaction of [Zn2Cu(L1) 2]5+ with Ba2+ deprograms the ligand and results in the formation of a mixture of species. The Royal Society of Chemistry.
N*-N*-S* Tridentate Ligand System as Potential Antitumor Agents
Antonini, Ippolito,Claudi, Francesco,Cristalli, Gloria,Franchetti, Palmarisa,Grifantini, Mario,Martelli, Sante
, p. 1181 - 1184 (2007/10/02)
Compounds containing an N*-N*-S* tridentate ligand were synthesized and tested for antitumor activity against P-388 lymphocytic leukemia in mice.Of these, only 2,2'-bipyridyl-6-carbothioamide (1a) showed antitumor activity
