78798-42-2Relevant academic research and scientific papers
STRUCTURE-ACTIVITY RELATIONSHIPS OF PSEUDOGUAIANOLIDES ISOLATED FROM GAILLARDIA PULCHELLA AND THEIR DERIVATIVES
Harimaya, Kenzo,Inayama, Seiichi
, p. 993 - 1008 (2007/10/02)
Three new pseudoguaianolides, 4-epipulchellin (1), 4-epineopulchellin (2) and pulchelloid D (3), were isolated from Gaillardia pulchella together with other eleven pseudoguaianolides and three guaianolides.Fifteen natural sesquiterpene lactones and their thirty one derivatives were tested for cytotoxic activity against KB cell line.Among them, twenty seven compounds were shown to be active (ED50 4 μg/ml).The structure-activity relationships of these sesquiterpene lactones are discussed.
ISOLATION AND STRUCTURE OF NEW PSEUDOGUAIANOLIDES,4-EPIPULCHELLIN AND 4-EPINEOPULCHELLIN FROM GAILLARDIA PULCHELLA
Harimaya, Kenzo,Hori, Hitoshi,Ohkura, Tamiko,Kawamata, Takeshi,Gao, Ji-Fu,Inayama, Seiichi
, p. 83 - 88 (2007/10/02)
The structure of 4-epipulchellin (1a) and 4-epineopulchellin (1b), new pseudoguaianolide sesquiterpene lactones isolated from Gaillarda pulchella, was determined on the basis of spectroscopic data and chemical transformations from pulchellin (2a) and neopulchellin (2b) into 1a and 1b, respectively.
