78831-19-3Relevant academic research and scientific papers
Synthesis of some new heterocyclic compounds derived from 3-formylchromones and their antimicrobial evaluation
Bari,Ali,Kadi,Hashmi,Ng
, p. 1723 - 1731 (2014/05/06)
The synthesis and antimicrobial evaluation of a series of chromone-linked substituted heterocyclic derivatives is described. The condensation of 3-formylchromone with acetoacetamide under Knoevenagel-Cope reaction conditions was also explored, and the condensation with 4-hydroxy-6-methyl-2H-pyran-2-one constitutes a facile route to pyranopyrone fused systems. Most of the compounds exhibit good antimicrobial properties.
The Synthesis of Pyridine Derivatives from 3-Formylchromone
Hass, Georges,Stanton, James L.,Sprecher, Andreas von,Wenk, Paul
, p. 607 - 612 (2007/10/02)
3-Formylchromone (1) reacts with active methylene derivatives to yield condensation products 2a-d, 10, 11 and 12.Treatment of 2a-d with ammonia or methylamine gives pyridines 3-6.Alternatively, reaction of 1 with enamine derivatives yields pyrido compounds 15,17,19,21,23 and 28 in one step.Factors determining the formation and regiospecifity of the pyridine ring forming reactions are also discussed.
