78840-01-4

Upstream product

• 35660-91-4 (E)-1-phenyl-2-buten-1-one 
• 495-41-0 1-phenylbut-2-en-1-one 
• 30383-01-8 lithium thioethoxide 
• 2524-64-3 chlorophosphoric acid diphenyl ester 

Downstream Products

• 51384-73-7 4-phenyl-3-penten-2-one 
• 78840-03-6 2-phenyl-4-ethylthio-2-pentene 

Relevant academic research and scientific papers

CROSS-COUPLING REACTION BETWEEN ENOL PHOSPHATES AND ORGANOALUMINIUM COMPOUNDS IN THE PRESENCE OF PALLADIUM(0) CATALYST.

The title reaction in the presence of a catalytic amount of tetrakis(triphenylphosphine)palladium(0) affords alkylative coupling products in good to excellent yields in 1,2-dichloroethane at room temperature. This coupling reaction under C(sp**2)-O cleavage proceeds stereospecifically. The reaction does not affect a coexisting vinyl sulfide group. This feature enables 1,2- and 1,3-carbonyl transposition with or without alkylation via phenylthio-substituted enol phosphates.

Pd(O) PROMOTED ALKYLATION OF ENOL PHOSPHATES WITH ORGANOALUMINIUM COMPOUNDS AND ITS SYNTHETIC APPLICATIONS

Keto carbonyl 1,2- and 1,3-transpositions with and without alkylation of the substrate are described together with ketone synthesis from thiocarboxylic S-ester.