78859-34-4

Basic information

• Product Name: (+)-CARAZOLOL
• Synonyms: (R)-4-(2-HYDROXY-3-ISOPROPYLAMINO-PROPOXY)-CARBAZOLE;(R)-1-(CARBAZOL-4-YLOXY)-3-(ISOPROPYLAMINO)-2-PROPANOL;(R,S)-CARAZOLOL;(R)-CARAZOLOL;CARVEDIOL;1-(CARBAZOL-4-YLOXY)-3-(ISOPROPYLAMINO)-2-PROPANOL;2-PROPANOL, 1-(9H-CARBAZOL-4-YLOXY)-3-[(1-METHYLETHYL)AMINO]-;2-PROPANOL, 1-(9H-CARBAZOL-4-YLOXY)-3-[(1-METHYLETHYL)AMINO], (2R)
• CAS NO: 78859-34-4
• Molecular Formula: C18H22N2O2
• Molecular Weight: 298.38
• EINECS: 260-945-1
• Mol File: 78859-34-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 531.2 °C at 760 mmHg
• Flash Point: 275.1 °C
• Appearance: /
• Density: 1.195 g/cm³
• Storage Temp.: 0-6°C
• PKA: 13.94±0.20(Predicted)
• Water Solubility: at 25 deg C (mg/L): 8.524
• CAS DataBase Reference: (+)-CARAZOLOL(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-CARAZOLOL(78859-34-4)
• EPA Substance Registry System: (+)-CARAZOLOL(78859-34-4)

Safety Data

• Hazardous Substances Data: 78859-34-4(Hazardous Substances Data)

Usage

Chemical Properties

Yellowish solid

Uses

(R)-Carazolol Hydrochloride is a β-adrenoceptor antagonist.

Upstream product

• 57775-29-8 carazolol 
• 591-20-8 3-Bromophenol 
• 75-31-0 isopropylamine 
• 95093-95-1 S-(+)-4-(oxiranylmethoxy)-9H-carbazole 
• 52602-39-8 9H-carbazol-4-ol 
• 123165-96-8 R-(+)-1-(carbazol-4-yloxy)-3-isopropylaminoprop-2-yl-β-D-glucopyranosyduronic acid 
• 117374-82-0 methyl uronate 
• 117374-83-1 methyl uronate 
• 117374-80-8 methyl <(R,S)-3-N-tert-butoxycarbonylisopropylamino-1-(carbazol-4-yloxy)prop-2-yl-2,3,4-tri-O-acetyl-β-D-glucopyranosid>uronate 
• 117374-78-4 (R,S)-3-N-tert-butoxycarbonylisopropylamino-1-(carbazol-4-yloxy)-2-propanol 

Relevant articles and documents

Synthesis of the glucuronide of carazolol.

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Chiral separations of some β-adrenergic agonists and antagonists on AmyCoat column by HPLC

Sixteen β-adrenergic antagonists namely acebutalol, alprenolol, atenolol, bisoprolol, bopindolol, bufurolol, carazolol, celiprolol, indenolol, metaprolol, nebivolol, oxprenolol, practolol, propranolol, tertalol, and timolol, and two β-adrenergic agonists namely cimeterol and clenbuterol were resolved on AmyCoat (150 x 46 mm, 3 μm size of silica particle) by using (85:15:0.1, v/v/v), (90:10:0.1, v/v/v), and (95:05:0.1, v/v/v) combinations of η-heptane, ethanol, and diethylamine solvents, respectively. The flow rates used were 0.5, 1.0, 2.0, and 3.0 ml/min with detection at 225 nm. The values of capacity, separation, and resolution factors ranged from 0.38 to 19.70, 1.08-2.33, and 1.0 and 4.50, respectively. The maximum and minimum resolutions were achieved for celiprolol and bufurolol, respectively. The chiral recognition mechanisms were also discussed. The values of validation parameters were calculated.