78874-27-8

Basic information

• Product Name: 5-(2,4-DICHLORO-PHENYL)-4H-PYRAZOLE-3-CARBOXYLIC ACID
• Synonyms: ART-CHEM-BB B020529;5-(2,4-DICHLOROPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID;5-(2,4-DICHLORO-PHENYL)-4H-PYRAZOLE-3-CARBOXYLIC ACID;AKOS B020529;3-(2,4-DICHLOROPHENYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID;1H-pyrazole-3-carboxylic acid, 5-(2,4-dichlorophenyl)-
• CAS NO: 78874-27-8
• Molecular Formula: C₁₀H₆Cl₂N₂O₂
• Molecular Weight: 257.07
• Mol File: 78874-27-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 512.3°C at 760 mmHg
• Flash Point: 263.6°C
• Appearance: /
• Vapor Pressure: 2.55E-11mmHg at 25°C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-(2,4-DICHLORO-PHENYL)-4H-PYRAZOLE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2,4-DICHLORO-PHENYL)-4H-PYRAZOLE-3-CARBOXYLIC ACID(78874-27-8)
• EPA Substance Registry System: 5-(2,4-DICHLORO-PHENYL)-4H-PYRAZOLE-3-CARBOXYLIC ACID(78874-27-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 78874-27-8(Hazardous Substances Data)

Usage

General Description

5-(2,4-Dichloro-phenyl)-4H-pyrazole-3-carboxylic acid is a chemical compound that belongs to the pyrazole carboxylic acid family. It is a white to off-white crystalline powder with a molecular formula of C10H5Cl2N3O2 and a molecular weight of 268.07 g/mol. 5-(2,4-DICHLORO-PHENYL)-4H-PYRAZOLE-3-CARBOXYLIC ACID is commonly used in the synthesis of pharmaceuticals, agrochemicals, and organic intermediates due to its versatile properties. It is a potent inhibitor of cyclooxygenase-2 (COX-2) and exhibits anti-inflammatory and analgesic properties. Additionally, it has been investigated for its potential use in the treatment of various diseases and conditions, including cancer and neurodegenerative disorders. Overall, 5-(2,4-Dichloro-phenyl)-4H-pyrazole-3-carboxylic acid is a valuable compound with diverse applications in various fields of research and industry.

InChI:InChI=1/C10H6Cl2N2O2/c11-5-1-2-6(7(12)3-5)8-4-9(10(15)16)14-13-8/h1-4H,(H,13,14)(H,15,16)/p-1

Upstream product

• 944783-94-2 C₁₁H₈Cl₂N₂O₂ 
• 78874-14-3 3-(2,4-Dichloro-benzoyl)-oxirane-2-carboxylic acid 
• 57045-35-9 (E)-4-(2,4-Dichloro-phenyl)-4-oxo-but-2-enoic acid 
• 78874-21-2 5-(2,4-Dichloro-phenyl)-4-hydroxy-3,4-dihydro-2H-pyrazole-3-carboxylic acid 
• 78874-33-6 4-(2,4-Dichloro-phenyl)-3-hydroxy-4-oxo-2-phenylamino-butyric acid 

Downstream Products

• 1119299-94-3 C₁₆H₁₈Cl₂N₄O 
• 1119299-95-4 C₁₆H₁₈Cl₂N₄O₂ 
• 1119300-00-3 C₁₆H₁₇Cl₂N₃O 
• 1119300-17-2 C₁₅H₁₇Cl₂N₃O 
• 1119300-12-7 C₁₄H₁₅Cl₂N₃O₂ 
• 1119300-16-1 C₁₄H₁₅Cl₂N₃O 
• 634889-56-8 C₁₀H₈Cl₂N₄O 
• 1119299-82-9 C₁₂H₁₁Cl₂N₃O₂ 
• 1119299-87-4 C₁₂H₁₁Cl₂N₃O 
• 1119299-85-2 C₁₃H₁₃Cl₂N₃O 
• 1119299-89-6 C₁₄H₁₅Cl₂N₃O 
• 1119300-18-3 C₁₄H₁₅Cl₂N₃O 

Relevant articles and documents

NOVEL NK-3 RECEPTOR SELECTIVE ANTAGONIST COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN NK-3 RECEPTORS MEDIATED DISORDERS

The present invention is directed to novel compounds of formula I and their use as therapeutic compounds.

Some Reactions of β-Aroylacrylic Acid Epoxides

β-Aroylacrylic acids (I) on reaction with hydrogen peroxide give α,β-epoxy-β-aroylacrylic acids (II) which on treatment with sodium hydroxide afford a mixture of arylmethyl 1,2-diketone (III) and arylmethyl glycollic acid (IV).The mixture is separated bei