78875-63-5

Usage

Uses

Used in Pharmaceutical Industry:
4-PHENYL-1,2,3-THIADIAZOLE-5-CARBOXYLIC ACID is used as a potential drug candidate for the treatment of various diseases due to its unique structure and biological activities.
Used in Agrochemical Industry:
4-PHENYL-1,2,3-THIADIAZOLE-5-CARBOXYLIC ACID is used as an antimicrobial and antifungal agent for controlling microbial and fungal infections in agriculture.
Used in Industrial Applications:
4-PHENYL-1,2,3-THIADIAZOLE-5-CARBOXYLIC ACID is used as a corrosion inhibitor to protect materials from corrosion in various industrial applications.

InChI:InChI=1/C9H6N2O2S/c12-9(13)8-7(10-11-14-8)6-4-2-1-3-5-6/h1-5H,(H,12,13)

Upstream product

• 58756-26-6 ethyl 4-phenyl-1,2,3-thiadiazole-5-carboxylate 

Downstream Products

• 78875-54-4 p-chlorophenyl 4-phenyl-1,2,3-thiadiazol-5-yl ketone 
• 78875-53-3 (4-Phenyl-[1,2,3]thiadiazol-5-yl)-p-tolyl-methanone 
• 78875-60-2 Phenyl-(4-phenyl-[1,2,3]thiadiazol-5-yl)-methanol 
• 78875-68-0 5-(Chloro-phenyl-methyl)-4-phenyl-[1,2,3]thiadiazole 
• 78875-61-3 (4-Phenyl-[1,2,3]thiadiazol-5-yl)-p-tolyl-methanol 
• 78875-69-1 5-(Chloro-p-tolyl-methyl)-4-phenyl-[1,2,3]thiadiazole 
• 78875-70-4 5-[Chloro-(4-chloro-phenyl)-methyl]-4-phenyl-[1,2,3]thiadiazole 
• 78875-62-4 (4-Chloro-phenyl)-(4-phenyl-[1,2,3]thiadiazol-5-yl)-methanol 
• 78875-52-2 phenyl 4-phenyl-1,2,3-thiadiazol-5-yl ketone 
• 1093255-55-0 N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-4-phenyl-1,2,3-thiadiazole-5-carboxamide 

Relevant academic research and scientific papers

Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling non-regulated necrosis. This form of cell death can be induced in an array of cell types in apoptotic deficient conditions with death receptor family ligands. A series of [1,2,3]thiadiazole benzylamides was found to be potent necroptosis inhibitors (called necrostatins). A structure-activity relationship study revealed that small cyclic alkyl groups (i.e. cyclopropyl) and 2,6-dihalobenzylamides at the 4- and 5-positions of the [1,2,3]thiadiazole, respectively, were optimal. In addition, when a small alkyl group (i.e. methyl) was present on the benzylic position all the necroptosis inhibitory activity resided with the (S)-enantiomer. Finally, replacement of the [1,2,3]thiadiazole with a variety of thiophene derivatives was tolerated, although some erosion of potency was observed.