78880-62-3Relevant articles and documents
Reaction of Malonaldehyde with Nucleic Acid. I. Formation of Fluorescent Pyrimidopurin-10(3H)-one Nucleosides
Seto, Hiroshi,Okuda, Taisuke,Takesue, Tomoyuki,Ikemura, Tadashi
, p. 1799 - 1802 (1983)
The reactions of malonaldehyde with guanosine and 2'-deoxyguanosine proceed slowly under acidic conditions to give new pyrimidopurine nucleosides, 3a and 3b, respectively.These compounds emit strong yellow fluorescence and are hydrolyzed by NaOH into malonaldehyde and guanosine from 3a (2'-deoxyguanosine from 3b).From chemical and spectroscopic evidence, these compounds were deduced to be 3-β-D-ribofuranosylpyrimidopurin-10(3H)-one (3a) and 3-(2-deoxy-β-D-erythro-pentofuranosyl)pyrimidopurin-10(3H)-one (3b).No products were detected in the reaction mixture of malonaldehyde with 1-methylguanosine, adenosine, cytidine, uridine, thymidine, 2'-deoxyadenosine, or 2'-deoxycytidine.
Reaction of malonaldehyde with nucleic acid. IV. Formation of pyrimido[1,2-a]purin-10(3H)-one nucleoside by thermal decomposition of diastereomers containing oxadiazabicyclononene residues linked to guanosine
Seto,Seto,Ohkubo,Saitoh
, p. 515 - 517 (2007/10/02)
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STRUCTURE OF A NEW MODIFIED NUCLEOSIDE FORMED BY GUANOSINE-MALONALDEHYDE REACTION
Seto, Hiroshi,Akiyama, Kazuyuki,Okuda, Taisuke,Hashimoto, Tsuyoshi,Takesue, Tomoyuki,Ikemura, Tadashi
, p. 707 - 708 (2007/10/02)
A new modified nucleoside was formed by the reaction of guanosine with malonaldehyde under acidic condition.This compound emitted strong yellow fluorescence and was hydrolyzed by NaOH into guanosine and malonaldehyde.Its structure was determined to be 1,N2-(1-propenyl-3-ylidene)guanosine by the spectroscopic analysis.