78906-65-7Relevant academic research and scientific papers
Synthesis and in vitro antimicrobial, antioxidant, and antiproliferative activities of some new pyrano[2,3-c]pyrazoles containing 1,2-azaphospholes, 1,3,2-diazaphosphinines and phosphonate moieties
Ali, Tarik E.,Assiri, Mohammed A.,El-Shaaer, Hafez M.,Abdel-Kariem, Somaia M.,Abdel-Monem, Wafaa R.,El-Edfawy, Somaya M.,Hassanin, Noha M.,Shati, Ali A.,Alfaifi, Mohammad Y.,Elbehairi, Serag Eldin I.
supporting information, p. 2478 - 2497 (2021/06/30)
New 1,2-azaphosphole, 1,3,2-diazaphosphinine, and phosphonate derivatives containing pyrano[2,3-c]pyrazole moiety were achieved. The synthetic pathways depended on the reaction of 6-amino-3-methyl-1,4-diphenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile with some phosphorus reagents such as diethyl phosphite, phosphorus sulfides, and phenyl phosphorus halides under different conditions. Compounds 6 and 7 recorded potent antibacterial and antifungal activities with lower toxicity, while compounds 4 and 6 displayed promising antioxidative properties. Further, compounds 4 and 9 exhibited potent cytotoxic effects against MCF-7, HepG-2, and HCT-116 cancer cells. The early apoptotic cell death was observed by the compounds in all types of the treated cells. Compounds 3, 5, 7, 10, and 14 recorded low to moderate percentages of necrosis and late apoptosis toward all treated cells.
STUDIES ON ORGANOPHOSPHORUS COMPOUNDS - XXXV. A NEW ROUTE TO 4-METHOXYPHENYLPHOSPHONOTHIOIC DIAMIDES FROM 2,4-BIS(4-METHOXYPHENYL)-1,3,2,4-DITHIADIPHOSPHETANE-2,4-DISULFIDE AND AMINES
Clausen, K.,El-Barbary, A. A.,Lawresson, S.-O.
, p. 1019 - 1026 (2007/10/02)
By reacting primary and secondary amines with 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide, 1A, at 25 deg C ammonium 4-methoxyphenylphosphonamidodithioates, 2, are formed.Upon heating to 140 deg C 2 eliminates hydrogen sulfide in a new type of reaction yielding 4-methoxyphenylphosphonothioic diamides, 3, which also are formed directly from primary amines and 1A at 140 deg C.For dibenzylamine some anomalous results are observed due to N->S rearrangement reactions.NMR spectroscopic data are presented for compounds 2 and 3.
