78907-19-4

Usage

Uses

Used in Pharmaceutical Synthesis:
2,3-Dihydro-4,7-dimethoxy-1H-inden-1-ol is used as a building block in the pharmaceutical industry for the synthesis of various drugs and medicinal products. Its unique chemical structure contributes to the development of new therapeutic agents.
Used in Organic Chemistry Research:
In the field of organic chemistry, 2,3-Dihydro-4,7-dimethoxy-1H-inden-1-ol serves as an important compound for research and experimentation, facilitating the discovery of novel chemical reactions and applications.
Used in Fragrance and Flavor Industry:
2,3-Dihydro-4,7-dimethoxy-1H-inden-1-ol is utilized as a component in the fragrance and flavor industry, where it imparts a distinctive aromatic profile to perfumes, scented products, and flavorings, enhancing their sensory appeal.

Upstream product

• 52428-09-8 4,7-dimethoxyindan-1-one 

Downstream Products

• 95838-87-2 2,5-Dimethoxy-6,6a-dihydro-1aH-1-oxa-cyclopropa[a]indene 

Relevant academic research and scientific papers

Simple and efficient synthesis of 4,7-dimethoxy-1(H)-indene

Stirring 4,7-dimethoxy-1-indanol in chloroform at room temperature in the presence of a catalytic amount of p-toluenesulfonic acid gave 4,7-dimethoxy-1(H)-indene in quantitative yield. Other solvents, including benzene, which was the most frequently used one for this reaction, gave mostly polymeric materials. The new method was also effective for dehydration of other electron-rich benzylic alcohols. Copyright Taylor & Francis Group, LLC.

Simple Preparation of β-Tetralones and β-Indanones by a 1,2-Carbonyl Group Transposition

By a four-step procedure, the ketones 3 are converted into the β-tetralones 7a-d and the β-indanones 7e, f via the intermediates 4, 5, and 6.

α-Adrenergic Agents. 1. Direct-Acting α1 Agonists Related to Methoxamine

A series of phenylethylamines related to methoxamine has been prepared and evaluated for direct α1-receptor agonist activity.It has been observed that for open-chain compounds such as methoxamine, in which the amine-containing portion is free to adopt numerous conformations, an hydroxyl group is necessary for direct α1-adrenergic activity.When the hydroxyl is removed, however, the direct component of activity is greatly reduced unless the amine is incorporated into a more sterically defined structure.From our studies we have concluded that in order for a phenylethylamine to be active as a direct α1-receptor agonist it should have a β nitrogen in a fully extended conformation relative to a substituted phenyl ring.For optimum potency, the nitrogen should be exocyclic to a saturated six-membered ring.It may be further incorporated exocyclic or endocyclic into an additional ring so long as the amine occupies a well-defined region of space relative to the aromatic portion of a molecule.The ED50 values of some of the more potent compounds as α1-receptor agonists are on the order of 1 * 10-7 M.