78939-37-4

Usage

Uses

Used in Chemical Synthesis:
DIMETHYL 2-OXOGLUTACONATE is used as a synthetic intermediate for the production of various chemical compounds and materials. Its unique structure allows it to be a versatile building block in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, DIMETHYL 2-OXOGLUTACONATE is used as a key intermediate in the synthesis of drugs and drug candidates. Its reactivity and functional groups enable the development of new therapeutic agents with improved efficacy and selectivity.
Used in Agrochemical Industry:
DIMETHYL 2-OXOGLUTACONATE is also utilized in the agrochemical industry as a precursor for the synthesis of pesticides and other crop protection agents. Its role in the production of these compounds helps to ensure the development of effective and environmentally friendly solutions for agriculture.
Used in Specialty Chemicals:
DIMETHYL 2-OXOGLUTACONATE finds application in the specialty chemicals sector, where it is employed as a starting material for the synthesis of various high-value products. Its unique properties and reactivity make it suitable for the production of dyes, fragrances, and other specialty chemicals.

Upstream product

• 148728-48-7 3-bromo-2-oxopentane-1,5-dioic acid dimethyl ester 
• 67-56-1 methanol 
• 328-50-7 α-ketoglutaric acid 
• 13192-04-6 dimethyl 2-ketoglutarate 

Downstream Products

• 89882-71-3 trimethyl 4-benzyloxy-1H-pyrrolo<2,3-f>quinoline-2,7,9-tricarboxylate 
• 133706-80-6 5-Methoxy-1H-pyrrolo<2,3-f>chinolin-2,7,9-tricarbonsaeure-(2-ethyl)(7,9-dimethyl)ester 
• 108334-73-2 methyl 2-Hydroxy-5-oxo-3-phenyl-2,5-dihydrofuran-2-carboxylate 
• 1404312-51-1 dimethyl 2-oxo-4-phenylpentanedioate 
• 73030-04-3 4,5-dihydro-5-hydroxy-4-oxo-5-(2-oxopropyl)-1H-pyrrolo<2,3-f>quinoline-2,7,9-tricarboxylic acid 
• 80721-47-7 4,5-Dihydro-4,5-dioxo-1H-pyrrolo<2,3-f>chinolin-2,7,9-tricarbonsaeure-(2-ethyl)(7,9-dimethyl)ester 
• 72909-34-3 pyrroloquinoline quinone 

Relevant academic research and scientific papers

Pyrroloquinoline quinone synthetic method

The invention discloses a synthetic method of pyrroloquinoline quinone. The synthetic method comprises the following steps: carrying out alkali treatment on 2-methoxy-5-nitroaniline hydrochloride as a raw material, so as to obtain a compound 1; carrying out formylation on the compound 1 under a catalysis condition of an ionic liquid, so as to obtain a compound 2; adopting sodium borohydride to reduce the compound 2 to obtain a compound 3; carrying out diazotization on the compound 3, and then enabling action between the diazotized compound 3 and HBF4 to obtain a compound 4; enabling reaction of the compound 4 and 2-methylethyl acetoacetate to obtain a compound 5; treating the compound 5 with formic acid to obtain a compound 6; carrying out amid catalysis and exchange with the ionic liquid on the compound 6 to obtain a compound 7; enabling reaction of the compound 7 and 2-oxodimethyl glutaconate to obtain a compound 8; feeding hydrogen chloride to the compound 8 under the action of Cu(OAc)2*2H2O to obtain a compound 9; carrying out basic hydrolysis on the compound 9 to obtain a compound 10. The synthetic method disclosed by the invention is cheap and accessible in raw materials, stable, high in reaction yield, quick in reaction, and easy for product separation, and is environment-friendly as the catalyst can be recycled.