78941-95-4

Basic information

• Product Name: IFLAB-BB F0349-0482
• Synonyms: IFLAB-BB F0349-0482;5-CHLORO-8-METHYL-QUINOLINE
• CAS NO: 78941-95-4
• Molecular Formula: C₁₀H₈ClN
• Molecular Weight: 177.63
• EINECS: -0
• Mol File: 78941-95-4.mol
• Article Data: 15

Chemical Properties

• Melting Point: 31-32 °C
• Boiling Point: 293.4±20.0 °C(Predicted)
• Appearance: /
• Density: 1.225±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly, Sonicated), Methanol (Slightly)
• PKA: 3.95±0.29(Predicted)
• CAS DataBase Reference: IFLAB-BB F0349-0482(CAS DataBase Reference)
• NIST Chemistry Reference: IFLAB-BB F0349-0482(78941-95-4)
• EPA Substance Registry System: IFLAB-BB F0349-0482(78941-95-4)

Safety Data

• Hazardous Substances Data: 78941-95-4(Hazardous Substances Data)

Usage

Chemical Properties

yellow powder

Uses

5-Chloro-8-methylquinoline can be used as an anticancer agent.

Upstream product

• 611-32-5 8-methylquinoline 
• 107-18-6 allyl alcohol 
• 95-79-4 5-chloro-2-methyl-benzenamine 
• 14002-34-7 tripropanolamine 
• 89-59-8 4-chloro-2-nitrotoluene 
• 56-81-5 glycerol 

Downstream Products

• 1609646-69-6 N-((5-chloroquinolin-8-yl)methyl)-4-(trifluoromethyl)benzenesulfonamide 
• 74316-57-7 8-methylquinoline-5-carbonitrile 
• 88474-17-3 5-iodo-8-methylquinoline 
• 88474-19-5 5-chloro-8-(bromomethyl)quinoline 
• 611-32-5 8-methylquinoline 
• 78941-93-2 7-Chloro-8-methylquinoline 

Relevant articles and documents

RhIII-Catalyzed Direct Heteroarylation of C(sp3)-H and C(sp2)-H Bonds in Heterocycles with N-Heteroaromatic Boronates

Herein, we disclose a RhIII-catalyzed heteroarylation of C(sp3)-H and C(sp2)-H bonds in heterocycles with organoboron reagents. This protocol displays high efficiency and excellent functional group tolerance. A range of heterocyclic boronates with strong coordinating atoms, including pyridine, pyrimidine, pyrazole, thiophene, and furan derivatives, can be extensively served as the coupling reagents. The direct heteroarylation method could supply potential application in terms of the synthesis of drug molecules with multiple heterocycles.

Cobalt-catalyzed ring-opening addition of azabenzonorbornadienes: Via C(sp3)-H bond activation of 8-methylquinoline

The first ring-opening addition of a benzylic C(sp3)-H bond to azabenzonorbornadienes is demonstrated. The reaction proceeded under the catalytic system of [Cp?CoI2(CO)], AgSbF6 and Fe(OAc)2 in PhOMe. The methodology showed a good substrate scope with up to 96 yield. The relative configuration of the product was determined as cis-configuration by X-ray crystallography.

Palladium-Catalyzed C-H Bond Functionalization Reactions Using Phosphate/Sulfonate Hypervalent Iodine Reagents

A new and operationally simple approach for palladium-catalyzed C-H functionalization reactions utilizing an organophosphorus/sulfonate hypervalent iodine reagent as both an oxidant and the source of a functional group has been developed. Through this method, the oxidative phosphorylation-, sulfonation-, and hydroxylation of unactivated benzyl C(sp3)-H bonds, along with the hydroxylation and arylation of aryl C(sp2)-H bonds, are successfully realized under mild conditions and with excellent site-selectivity. The versatile C-OSO2R bond provides a platform for a wide array of subsequent diversification reactions.