789488-36-4Relevant academic research and scientific papers
Synthesis and inhibitory activity evaluation of 2,6-disubstituted purine derivatives
Liu, Hongxia,Li, Libo,Qurat-Ul-Ain, Shaikh,Jiang, Tao
, p. 473 - 477 (2015/03/30)
A series of novel 2,6-disubstituted purine derivatives were designed and synthesized from 2,6-dichloropurine. The structures of target compounds were determined by 1H-NMR, 13C-NMR, and HRMS. The synthesized compounds were evaluated for their inhibitory activities against lung cancer cell lines of A549 and liver cancer cell lines of Bel-7402. 2-(4-Benzyloxy-phenylamino)-6-(cyclohexylamino)purine(3), 2-(4-chloro-phenylamino)-6-(n-butylamino)purine (5), 2-(4-morpholinoamino)-6-(4-hydroxy-phenylamino)purine (9), and 2-(4-O-galactosyl-phenylamino)-6-(cyclohexylamino)purine (12) exhibited moderate inhibitory activity.
Synthesis and screening of 2,6-diamino-substituted purine derivatives as potential cardiomyogenesis inducing agents
Koley, Moumita,K?nig, Xaver,Hilber, Karlheinz,Schnürch, Michael,Stanetty, Peter,Mihovilovic, Marko D.
, p. 45 - 61 (2011/06/18)
The synthesis of 2,6-diamino-substituted purines is reported starting from 2,6-dichloropurine via two subsequent selective nucleophilic substitution reactions. The first substitution takes place selectively in 6-, the second in 2-position. The compounds w
A practical synthesis of 2-arylamino-6-alkylaminopurines from 2,6-dichloropurine
Ciszewski, Lech,Waykole, Liladhar,Prashad, Mahavir,Repic, Oljan
, p. 799 - 802 (2012/12/22)
A practical synthesis of N-[4-(6-cyclobutylamino-9H-purin-2-ylamino)- phenyl]-N-methyl acetamide (QAB205, 5a), an anti-asthmatic agent, is described from 2,6-dichloropurine (1) by base-assisted substitution of the 6-chloro substituent with cyclobutylamine
