789488-77-3

Basic information

• Product Name: 6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone hydrochloride
• Synonyms: 6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone hydrochloride;ENMD-1068 hydrochloride;ENMD-1068
• CAS NO: 789488-77-3
• Molecular Formula: C15H30ClN3O2
• Molecular Weight: 319.8706
• Mol File: 789488-77-3.mol
• Article Data: 0

Chemical Properties

• Appearance: white to beige/
• Storage Temp.: 2-8°C
• Solubility: H2O: soluble25mg/mL, clear
• CAS DataBase Reference: 6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone hydrochloride(789488-77-3)
• EPA Substance Registry System: 6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone hydrochloride(789488-77-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 46
• WGK Germany: 3
• Hazardous Substances Data: 789488-77-3(Hazardous Substances Data)

Usage

Description

6-Amino-1-[4-(3-methylbutanoyl)piperazin-1-yl]hexan-1-one is a complex organic compound with a unique molecular structure that features a 6-amino group, a hexan-1-one backbone, and a 4-(3-methylbutanoyl)piperazin-1-yl substituent. 6-Amino-1-[4-(3-methylbutanoyl)piperazin-1-yl]hexan-1-one is characterized by its potential biological activity and diverse applications in various fields.

Uses

Used in Pharmaceutical Industry:
6-Amino-1-[4-(3-methylbutanoyl)piperazin-1-yl]hexan-1-one is used as a protease-activated receptor 2 (PAR2) antagonist for investigating the pathway responsible for paw edema induced by Crotalus durissus terrificus venom serine protease (Cdtsp 2). This application is crucial in understanding the molecular mechanisms underlying the inflammatory response and developing targeted therapies for various inflammatory conditions.
Used in Research and Development:
6-Amino-1-[4-(3-methylbutanoyl)piperazin-1-yl]hexan-1-one serves as a valuable compound in the field of medicinal chemistry and drug discovery. Its unique structure and functional groups make it a promising candidate for the development of new drugs and therapeutic agents. Researchers can use this compound as a starting point for designing and synthesizing novel molecules with improved pharmacological properties and therapeutic potential.
Used in Chemical Synthesis:
6-Amino-1-[4-(3-methylbutanoyl)piperazin-1-yl]hexan-1-one can be employed as a key intermediate in the synthesis of various complex organic molecules and pharmaceutical agents. Its versatile structure allows for further functionalization and modification, enabling the development of new compounds with diverse applications in different industries.

Biochem/physiol Actions

ENMD-1068 is an antagonist of protease-activated receptor 2 (PAR2). The compound blocks TNFα production in synovial explants from patients with arthritis, and inhibits mast cell tryptase-induced recruitment of eosinophils into the pleural cavity of mice.