22-NBD cholesterol is a fluorescent analog of cholesterol that contains a fluorescent nitrobenzoxadiazole (NBD) group. It has been used in a variety of in vitro and in vivo applications, including analysis of steroid uptake and esterification, intracellular localization and targeting, and metabolism in mammalian and bacterial cells, and intestinal absorption of cholesterol in hamsters. 22-NBD cholesterol displays excitation/emission maxima of 472/540 nm, respectively, when incorporated into 1,2-dimyristoyl-sn-glycero-3-PC (DMPC) vesicles. The emission maximum of 22-NBD cholesterol is solvent-dependent and increases as solvent polarity increases.
78949-95-8
Post Buying Request-
-
Basic information
- Product Name: 22-NBD CHOLESTEROL
- Synonyms: N-(7-nitrobenz-2-oxa-1,3-diazole)-23,24-dinor-5-cholen-22-amine-3beta-ol;NBD cholesterol [22-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)aMino)-23,24-bisnor-5-cholen-3b-ol];NBD cholesterol, 90%
- CAS NO:78949-95-8
- Molecular Formula: C28H38N4O4
- Molecular Weight: 494.62572
- EINECS: N/A
- Product Categories: N/A
- Mol File: 78949-95-8.mol
-
Chemical Properties
- Melting Point: N/A
- Boiling Point: 650.5°Cat760mmHg
- Flash Point: 347.2°C
- Appearance: /
- Density: 1.27g/cm3
- Vapor Pressure: 8.28E-18mmHg at 25°C
- Refractive Index: 1.622
- Storage Temp.: N/A
- Solubility: N/A
- PKA: 15.03±0.70(Predicted)
- CAS DataBase Reference: 22-NBD CHOLESTEROL(CAS DataBase Reference)
- NIST Chemistry Reference: 22-NBD CHOLESTEROL(78949-95-8)
- EPA Substance Registry System: 22-NBD CHOLESTEROL(78949-95-8)
-
Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: 22-24/25
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 78949-95-8(Hazardous Substances Data)
78949-95-8 Suppliers
Recommended suppliers
78949-95-8 Usage
Uses
Used in Research and Development:22-NBD cholesterol is used as a research tool for studying [application reason] the uptake, esterification, and metabolism of cholesterol in mammalian and bacterial cells. Its fluorescent properties allow for easy tracking and analysis of cholesterol-related processes within cells.
Used in Pharmaceutical Industry:
22-NBD cholesterol is used as a diagnostic agent for [application reason] investigating the intestinal absorption of cholesterol in hamsters, which can provide insights into cholesterol metabolism and its role in various diseases.
Used in Analytical Chemistry:
22-NBD cholesterol is used as a marker in [application reason] determining the solvent polarity in different environments, as its emission maximum increases with increasing solvent polarity.
Used in Cell Biology:
22-NBD cholesterol is used as a fluorescent probe for [application reason] intracellular localization and targeting of cholesterol within cells, aiding in the understanding of cellular processes and functions related to cholesterol.
Check Digit Verification of cas no
The CAS Registry Mumber 78949-95-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,9,4 and 9 respectively; the second part has 2 digits, 9 and 5 respectively.Calculate Digit Verification of CAS Registry Number 78949-95:
(7*7)+(6*8)+(5*9)+(4*4)+(3*9)+(2*9)+(1*5)=208
208 % 10 = 8
So 78949-95-8 is a valid CAS Registry Number.
InChI:InChI=1/C28H38N4O4/c1-16(15-29-23-8-9-24(32(34)35)26-25(23)30-36-31-26)20-6-7-21-19-5-4-17-14-18(33)10-12-27(17,2)22(19)11-13-28(20,21)3/h4,8-9,16,18-22,29,33H,5-7,10-15H2,1-3H3/t16-,18+,19+,20-,21+,22+,27+,28-/m1/s1
78949-95-8Upstream product
78949-95-8Downstream Products
Post a RFQ
1
What can I do for you?
Get Best Price
Get Best Price for 78949-95-8
22-NBD CHOLESTEROL
