78956-15-7Relevant academic research and scientific papers
Copper-catalyzed enantioselective carbonylation toward α-chiral secondary amides
Wu, Xiao-Feng,Yuan, Yang,Zhao, Fengqian
, p. 12676 - 12681 (2021/10/19)
Secondary amides are omnipresent structural motifs in peptides, natural products, pharmaceuticals, and agrochemicals. The copper-catalyzed enantioselective hydroaminocarbonylation of alkenes described in this study provides a direct and practical approach for the construction of α-chiral secondary amides. An electrophilic amine transfer reagent possessing a 4-(dimethylamino)benzoate group was the key to the success. This method also features broad functional group tolerance and proceeds under very mild conditions, affording a set of α-chiral secondary amides in high yields (up to 96% yield) with unprecedented levels of enantioselectivity (up to >99% ee). α,β-Unsaturated secondary amides can also be produced though the method by using alkynes as the substrate.
Cobalt-rhodium heterobimetallic nanoparticle-catalyzed synthesis of α,β-unsaturated amides from internal alkynes, amines, and carbon monoxide
Park, Ji Hoon,Kim, Sun Young,Kim, Soo Min,Chung, Young Keun
, p. 2465 - 2468 (2008/02/05)
The first example of cobalt-rhodium heterobimetallic nanoparticle-catalyzed synthesis of alkenyl amides from alkynes, amines, and carbon monoxide is described.
A novel carbonylative decomplexation of alkyne-dicobalt hexacarbonyls: Hyrocarbamoylation of alkynes
Sugihara, Takumichi,Okada, Yoshinari,Yamaguchi, Masahiko,Nishizawa, Mugio
, p. 768 - 770 (2007/10/03)
A novel carbonylative decomplexation of alkyne-dicobalt hexacarbonyls, i.e. hydrocarbamoylation of alkynes, was carried out by reaction of the complexes with 10 equiv, of primary and secondary amines.
On the Reaction of Diphenylcyclopropenone, its Functional Derivatives and Imonium Salts with Amines
Eicher, Theophil,Boehm, Siegfried,Ehrhardt, Heinz,Harth, Robert,Lerch, Dieter
, p. 765 - 788 (2007/10/02)
The reactions of cyclopropenones 1, 2, cyclopropenone imines 3 and cyclopropenone imonium cations 5 with amines of different type are investigated and the structure of the products obtained is elucidated by means of spectral data and chemical behavior.The possible reaction modes and mechanisms are discussed.
