78984-91-5Relevant academic research and scientific papers
Catalytic Direct Construction of Cyano-tetrazoles
Ma, Jun-An,Peng, Xing,Xiao, Ming-Yang,Xue, Xiao-Song,Zhang, Fa-Guang,Zheng, Meng-Meng
, p. 7762 - 7767 (2020)
Cyano-tetrazole is the first reported compound that bears four nitrogen atoms in a single five-membered ring. This unique molecular scaffold has long been ignored after its discovery in 1885, mainly attributed to the scarcity of available synthetic methods. Indeed, the most popular approach to tetrazoles (that is the cycloaddition reaction between nitriles and azides) has inevitably excluded the possibility of introducing valuable cyano groups to decorate the final heterocyclic cores. Here, we describe a completely different disconnection strategy to the long time-pursued cyano-tetrazoles via a simple, direct, and practical cycloaddition transformation between readily accessible aryl diazonium salts and diazoacetonitrile. This method provides both regioisomers of disubstituted tetrazoles from the same set of starting materials in a metal cation controlled fashion.
1-aryl-tetrazole-5-nitrile, 2-aryl-tetrazole-5-nitrile, and preparation method thereof
-
Paragraph 0130-0132, (2020/05/05)
The invention discloses 1-aryl-tetrazole-5-nitrile, 2-aryl-tetrazole-5-nitrile and a preparation method thereof. According to the preparation method, aryl diazonium salt is used as an initial raw material, and under the catalytic action of silver salts, 2
