78987-04-9

Usage

Uses

Used in Pharmaceutical Industry:
[(6R,6aR)-8,9-dimethoxy-6,11,12,14-tetrahydro-6aH-[1,3]dioxolo[4,5-h]isoquino[2,1-b]isoquinolin-6-yl]methanol may be used as a pharmaceutical compound for [application reason] due to its unique structure and potential pharmacological properties. Further research and development are required to explore its full potential in this industry.
Used in Research and Development:
In the field of research and development, [(6R,6aR)-8,9-dimethoxy-6,11,12,14-tetrahydro-6aH-[1,3]dioxolo[4,5-h]isoquino[2,1-b]isoquinolin-6-yl]methanol can be used as a research compound for [application reason], such as studying its interactions with biological systems or evaluating its potential as a therapeutic agent. Its complex structure and the presence of various functional groups make it an intriguing candidate for scientific exploration.

Upstream product

• 78987-00-5 (+/-)-trans-2,3-Dimethoxy-8-oxo-9,10-(methylenedioxy)-13-(methoxycarbonyl)tetrahydroprotoberberine 
• 66271-20-3 6-bromo-5-carboxymethyl-benzo[1,3]dioxole-4-carboxylic acid 
• 66271-19-0 5-bromo-6H-indeno[4,2-d][1,3]dioxole-7,8-dione-7-oxime 
• 66303-84-2 2-carboxy-3,4-(methylenedioxy)phenylacetic acid 
• 56920-74-2 3-(2-bromo-4,5-methylenedioxyphenyl)propionic acid 
• 38699-84-2 4-bromo-6,7-methylenedioxy-1-indanone 
• 78986-98-8 (+/-)-trans-2,3-Dimethoxy-8-oxo-9,10-(methylenedioxy)-13-carboxytetrahydroprotoberberine 
• 75267-21-9 anhydride of 3,4-methylenedioxyhomophthalic acid 
• 3382-18-1 6,7-dimethoxy-3,4-dihydro-isoquinoline 

Downstream Products

• 79082-02-3 (+/-)-Thalictrifoline 
• 78987-05-0 Toluene-4-sulfonic acid (6S,6aS)-8,9-dimethoxy-6,11,12,14-tetrahydro-6aH-[1,3]dioxolo[4,5-h]isoquino[2,1-b]isoquinolin-6-ylmethyl ester 

Relevant academic research and scientific papers

Studies in Protoberberine Alkaloids: Part XIX - Synthesis of (+/-)-Thalictrifoline, (+/-)-Sinactine and (+/-)-Cavidine

(+/-)-Thalictrifoline (14), (+/-)-sinactine (13) and (+/-)-cavidine (18) have been synthesised from trans- and cis-13-carboxy-9,10-methylenedioxy-2,3-dimethoxy-8-oxo-tetrahydroprotoberberines (8 and 9). 8 and 9 are obtained by condensing 3,4-methylenedioxyhomophthalic anhydride (6) and 6,7-dimethoxyisoquinoline (7).

Absolute Configurations of the cis- and trans-13-Methyltetrahydroprotoberberines. Total Synthesis of (+)-Thalictricavine, (+)-Canadine, (+/-)-, (-)-, and (+)-Thalictrifoline, and (+/-)-, (-)-, and (+)-Cavidine

The tetrahydroprotoberberine alkaloids (+)-thalictricavine and (+)-canadine have been synthesized from an optically resolved (+)-13-carboxy-7,8,13,14-tetrahydro-9-oxoprotoberberine .This establishes the absolute configuration of (+)-thalictricavine as 13S,14R. (+)-Thalictrifoline and (+)-cavidine have also been prepared from a common intermediate, (+)-32, whose absolute configuration was established by correlation with (+)-26.This determines the absolute configuration of (+)-thalictrifoline as 13R,14R, of (+)-corydalic acid methyl ester (22) as 3R,4R, and of the protopine (+)-corycavine (20) as 13R.