78993-82-5

Upstream product

• 90-02-8 salicylaldehyde 
• 103-72-0 phenyl isothiocyanate 
• 2198-64-3 N-Benzoylalanine 
• 779-84-0 N-phenylsalicylaldimine 
• 51127-13-0 2-phenyl-4-methyl-4H-oxazolin-5-one 

Relevant academic research and scientific papers

Isothiocyanate-Mediated Condensation of N-Acyl-α-amino Acids with Aromatic Aldehydes: One-Pot Synthesis of 1,2-Disubstituted 4-Arylmethylene-2-imidazolin-5-ones

N-Acetyl/benzoyl-amino acids (1c/1b, d) when heated with isothiocyanates (2) in the presence of suitable aromatic aldehydes (3) with pyridine as a catalyst, afford 1, 2-disubstituted 4-arylmethylene-2-imidazolin-5-ones (6).However, N-benzyloxycarbonylaminoacetic acid (1a) gives the corresponding anilide (11a).Mechanisms of these reactions are discussed.

Reactions of 2-Phenyl-2-oxazolin-5-ones with Imines and Their Corresponding Carbonyl Compounds

The addition of 2-phenyl-2-oxazolin-5-ones (3) to benzylideneaniline, salicylideneaniline, benzaldehyde or salicylaldehyde affords different products depending upon the nature of the reactants.