78998-95-5Relevant academic research and scientific papers
Transannular Enantioselective (3 + 2) Cycloaddition of Cycloalkenone Hydrazones under Br?nsted Acid Catalysis
Sendra, Jana,Reyes, Efraim,Prieto, Liher,Fernández, Elena,Vicario, Jose L.
supporting information, p. 8738 - 8743 (2021/11/20)
Hydrazones derived from cycloalkenones undergo an enantioselective transannular formal (3 + 2) cycloaddition catalyzed by a chiral phosphoric acid. The reaction provides high yields and excellent stereocontrol in the formation of complex adducts with one or two α-tertiary amine moieties at the ring fusion, and these can be converted into very versatile stereodefined decalin- or octahydro-1H-indene-derived 1,3-diamines through simple reductive N-N cleavage.
Enantioselective catalytic transannular ketone-ene reactions
Rajapaksa, Naomi S.,Jacobsen, Eric N.
, p. 4238 - 4241 (2013/09/12)
Highly enantio-and diastereoselective transannular ketone-ene reactions are catalyzed by a new chromium(III) triflate tridentate Schiff base complex. Electronically unactivated keto-olefins undergo heteroene reactions at ambient temperature to afford enantioenriched bicyclic alcohols, common structural motifs in natural products. The kinetic resolution of a configurationally stable planar-chiral cyclodecenone is also described.
Tandem oxy-Cope/transannular ene reaction of 1,2-divinylcyclohexanols
Warrington, Jeffrey M.,Yap, Glenn P. A.,Barriault, Louis
, p. 663 - 665 (2007/10/03)
Graph Presented The syntheses via tandem oxy-Cope/transannular ene reaction of 1,2-divinylcyclohexanols to bi-and tricyclic skeletons are described. This strategy generates a rapid method for the preparation of advanced polycyclic intermediates with high
