790184-33-7

Basic information

• Product Name: (R)-2-Methylmorpholine
• Synonyms: (R)-2-Methyl-morpholine;Morpholine, 2-Methyl-, (2R)-
• CAS NO: 790184-33-7
• Molecular Formula: C₅H₁₁NO
• Molecular Weight: 101.15
• Mol File: 790184-33-7.mol

Chemical Properties

• Boiling Point: 137℃
• Flash Point: 41℃
• Appearance: /
• Density: 0.891
• PKA: 9.01±0.40(Predicted)
• CAS DataBase Reference: (R)-2-Methylmorpholine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-Methylmorpholine(790184-33-7)
• EPA Substance Registry System: (R)-2-Methylmorpholine(790184-33-7)

Safety Data

• Hazardous Substances Data: 790184-33-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(R)-2-Methylmorpholine is used as a solvent, catalyst, and corrosion inhibitor for the manufacturing of pharmaceuticals. Its properties facilitate various chemical reactions and processes in the production of drugs, enhancing the efficiency and effectiveness of pharmaceutical formulations.
Used in Agrochemical Industry:
In the agrochemical industry, (R)-2-Methylmorpholine serves as a solvent and catalyst, aiding in the synthesis of agrochemicals such as pesticides and herbicides. Its ability to dissolve and react with various compounds makes it a valuable component in the development of agricultural products.
Used in Rubber Chemical Industry:
(R)-2-Methylmorpholine is utilized as a solvent and catalyst in the production of rubber chemicals. It contributes to the manufacturing process by enabling the synthesis of various rubber additives and accelerators, improving the performance and quality of rubber products.
Used in Polyurethane Foam Production:
(R)-2-Methylmorpholine is used as a catalyst in the production of polyurethane foams. Its catalytic properties help in the polymerization process, resulting in the formation of polyurethane foams with desired properties for various applications, such as insulation, cushioning, and upholstery.
Used as a Stabilizer in Dyeing Process:
In the textile industry, (R)-2-Methylmorpholine is used as a stabilizer during the dyeing process. It helps in maintaining the stability of dyes and improving the colorfastness of fabrics, ensuring consistent and long-lasting coloration.
Used in Organic Synthesis:
(R)-2-Methylmorpholine is employed as a reactant in organic synthesis due to its strong base and nucleophilic properties. It is involved in the production of various chemical compounds, contributing to the synthesis of new molecules with potential applications in different industries.
It is important to handle (R)-2-Methylmorpholine with caution, as it can be hazardous if not properly managed. Proper safety measures should be taken to ensure the safe use of this chemical in various applications.

Upstream product

• 120800-90-0 (R)-4-benzyl-2-methylmorpholine 
• 127958-66-1 (6R)-6-methylmorpholin-3-one 
• 454251-71-9 (2S,4aS,7R,8aR)-N-allyl-2-hydroxymethyl-4,4,7-trimethyl-octahydro-1,3-benzoxazine 
• 914359-85-6 (3S,6aS,9R,10aR,11aS)-3-phenylselenenylmethyl-6,6,9-trimethyl-decahydro-3H,7H-[1,4]oxazino[3,4-b][1,3]benzoxazine 
• 914360-11-5 (2R)-4-(8-mentholyl)-2-methyl-morpholine 
• 914359-99-2 (3R,6aS,9R,10aR,11aS)-3,6,6,9-tetramethyl-decahydro-3H,7H-[1,4]oxazino[3,4-b][1,3]benzoxazine 

Downstream Products

• 1257234-85-7 2-[(2R)-2-methylmorpholin-4-yl]-N-[6-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-2-yl]acetamide 
• 1257234-87-9 2-[(2S)-2-methylmorpholin-4-yl]-N-[6-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-2-yl]acetamide 
• 1257234-97-1 2-[(2R)-2-methylmorpholin-4-yl]-N-[6-(2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidin-9-yl)dibenzothiophen-2-yl]acetamide 
• 1257234-83-5 N-methyl-2-[(2R)-2-methylmorpholin-4-yl]-N-[6-(2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidin-9-yl)dibenzo[b,d]thiophen-2-yl]acetamide 

Relevant articles and documents

Preparation method of chiral morpholine compound

The invention provides a preparation method of a chiral morpholine compound. With chiral ethylene oxide as a raw material, the preparation method comprises the steps of ring opening, cyclization and deprotection reaction to obtain the chiral 2-substituted morpholine compound. The preparation process is simple and environmentally friendly, has mild reaction conditions, is free of irritation or allergens, has higher total yield and good safety and is suitable for industrial amplification.

A concise and efficient synthesis of substituted morpholines

A simple and efficient method has been developed for the synthesis of substituted morpholines by a sequence of coupling, cyclization, and reduction reactions of easily available amino alcohols and α-halo acid chlorides. Various mono-, di-, and trisubstituted morpholines, spiro morpholines, and ring-fused morpholines, as well as morpholine homologues, were synthesized in good to excellent yields by a single methodology under similar reaction conditions. The method was also used in a multigram synthesis of (3S)-3-methylmorpholine.

DIBENZOTHIOPHENE DERIVATIVES AS DNA- PK INHIBITORS

Compound formula I: wherein: X1 and X2 may be either (a) C and O, (b) N and N, or (c) C and NH, where the dotted bonds represents a double bond in the appropriate location; R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, an optionally substituted C3-20 heterocyclyl group, or an optionally substituted C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; RN1 is selected from hydrogen and an optionally substituted C1-4 alkyl group; RC1 is selected from an optionally substituted C1-7 alkyl group, an optionally substituted C3-20 heterocyclyl group, or an optionally substituted C5-20 aryl group; or RN1 and RC1 may together form an optionally substituted C2-4 alkylene group.

Diastereoselective synthesis of enantiopure morphelines by electrophilic selenium-induced 6-exo cyclizations on chiral 3-allyl-2-hydroxymethylperhydro-1, 3-benzoxazine derivatives

Enantiopure morpholine derivatives have been prepared by selenocyclofunctionalization of chiral 3-allyl-2-hydroxymethyl-substituted perhydro-1,3-benzoxazine derivatives. The cyclization occurs in high yields and diastereoselection, although the temperature of the reaction and the structure of the substituent at C-2 and the substitution pattern of the double bond can modify the regio- and stereochemistry of the final products.