790203-84-8 Usage
Uses
Used in Cardiovascular Medicine:
(S)-3-AMINO-3-(4-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID is used as an antiplatelet agent for the prevention of blood clots in patients with unstable angina or a history of heart attack. It is particularly effective in reducing the risk of further heart-related events by inhibiting the platelet aggregation process, which is a key factor in the development of thrombi.
Used in Combination Therapy:
In the treatment of cardiovascular conditions, (S)-3-AMINO-3-(4-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID is used in conjunction with other medications such as aspirin and heparin. This combination therapy enhances the overall efficacy of treatment by providing a multifaceted approach to preventing blood clot formation and reducing the risk of ischemic events.
Used in Acute Coronary Syndrome Management:
(S)-3-AMINO-3-(4-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID is also used in the management of acute coronary syndrome, where it helps to stabilize patients by reducing the likelihood of thrombotic complications during the critical phase of the condition.
Used in Interventional Cardiology:
During percutaneous coronary intervention (PCI) procedures, such as angioplasty and stenting, (S)-3-AMINO-3-(4-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID is used to minimize the risk of thrombotic events that can occur as a result of the invasive procedure.
Check Digit Verification of cas no
The CAS Registry Mumber 790203-84-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,9,0,2,0 and 3 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 790203-84:
(8*7)+(7*9)+(6*0)+(5*2)+(4*0)+(3*3)+(2*8)+(1*4)=158
158 % 10 = 8
So 790203-84-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H10F3NO2/c11-10(12,13)7-3-1-6(2-4-7)8(14)5-9(15)16/h1-4,8H,5,14H2,(H,15,16)/t8-/m0/s1
790203-84-8Relevant academic research and scientific papers
Stereoselective chemoenzymatic preparation of β-amino esters: Molecular modelling considerations in lipase-mediated processes and application to the synthesis of (S)-dapoxetine
Rodriguez-Mata, Maria,Garcia-Urdiales, Eduardo,Gotor-Fernandez, Vicente,Gotor, Vicente
supporting information; experimental part, p. 395 - 406 (2010/06/15)
A wide range of optically active 3-amino-3-arylpropanoic acid derivatives have been prepared by means of a stereoselective chemoenzymatic route. The key step is the kinetic resolution of the corresponding β-amino esters. Although the enzymatic acylations of the amino group with ethyl methoxyacetate showed synthetically useful enantioselectivities, the hydrolyses of the ester group catalyzed by lipase from Pseudomonas cepacia have been identified as the optimal processes concerning both activity and enantioselectivity. The enantiopreference of this lipase in these reactions has been explained, at the molecular level, by using a fragment-based approach in which the most favoured binding site for a phenyl ring and the most stable conformation of the 3-aminopropanoate core nicely match the (S)-configuration of the major products. The conversion and enantioselectivity values of the enzymatic reactions have been compared in order to understand the influence of the different substitution patterns present in the phenyl ring. This chemoenzymatic route has been successfully applied to the preparation of a valuable intermediate in the synthesis of (S)-dapoxetine, which has been chemically synthesised in excellent optical purity.
