79030-60-7Relevant articles and documents
1--3-substituted-aminopropanes and 2-Propanols as Potential Biodynamic Agents
Sangwan, Naresh K.,Rastogi, Shri Nivas
, p. 480 - 483 (2007/10/02)
2-Acetyl-4-(propionyl/bromo)phenols (3/4), prepared from 4-(propionyl/bromo)phenyl acetates (1/2), on alkylation with 1,3-dihalopropanes or epichlorohydrin gives the corresponding 3-halopropyl (5,6) and 2,3-epoxypropyl (7,8) ethers.Treatment of 5-8 with amines under suitable conditions yields the title compounds, 1-(2'-acetyl-4'-propionylphenoxy)-3-substituted-aminopropanes (9-11) and 1--3-substituted-amino-2-propanols (15-22).The corresponding β-pyrrolidinoethyl ethers (13,14) are prepared by alkylation of 3 and 4 with N-(β-chloroethyl)pyrrolidine.Dehydration of 10, 17 and 21 gives 12, 23 and 24, while reduction of 15 and 20 with KBH4 gives 25 and 26, respectively.Reaction of 3 and 4 with 0.5 mol of 1,3-dibromopropane and of 7 with 3 gives the corresponding 1,3-bis-aryloxypropanes (27,28) and 1,3-bis-aryloxy-2-propanol (29).Except 11 which exhibits antiinflammatory activity, no other compound shows any significant pharmacological activity.