79032-48-7 Usage
Uses
Different sources of media describe the Uses of 79032-48-7 differently. You can refer to the following data:
1. The D-isomer of SNAP. Serves as an NO donor
2. The D-isomer of SNAP. Serves as an NO donor.
Definition
ChEBI: A nitroso compound that is N-acetyl-D-penicillamine in which the sulfanyl hydrogen is replaced by a nitroso group.
General Description
Nitric oxide donor that begins to evolve nitric oxide immediately upon solubilization in aqueous buffers (t1/2 = 10 h). Mimics the actions of nitric oxide, including the relaxation of isolated bovine coronary artery rings (EC50 = 130 nM). Markedly activates soluble guanylate cyclase. Also reported to cause the reversible inactivation of protein kinase C activity. Induces apoptosis in mouse thymocytes. Note: 1 set = 4 x 5 mg.
Biological Activity
A stable analog of endogenous S-nitroso compounds. A source of NO in vivo which unlike organic O-nitrates does not induce tolerance. Decomposes slowly in solution with a t ?of 37h.
Biochem/physiol Actions
EC50 = 130 nM in relaxation of isolated bovine coronary artery rings
Check Digit Verification of cas no
The CAS Registry Mumber 79032-48-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,9,0,3 and 2 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 79032-48:
(7*7)+(6*9)+(5*0)+(4*3)+(3*2)+(2*4)+(1*8)=137
137 % 10 = 7
So 79032-48-7 is a valid CAS Registry Number.
InChI:InChI=1/C7H12N2O4S/c1-4(10)8-5(6(11)12)7(2,3)14-9-13/h5H,1-3H3,(H,8,10)(H,11,12)/t5-/m0/s1
79032-48-7Relevant articles and documents
Synergistic activity of acetohydroxamic acid on prokaryotes under oxidative stress: The role of reactive nitrogen species
Yadav, Reeta,Goldstein, Sara,Nasef, Mohamed O.,Lee, Wendy,Samuni, Uri
, p. 291 - 297 (2014)
One-electron oxidation of acetohydroxamic acid (aceto-HX) initially gives rise to nitroxyl (HNO), which can be further oxidized to nitric oxide (NO) or react with potential biological targets such as thiols and metallo-proteins. The distinction between th
NITROSATION REAGENTS AND METHODS
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Paragraph 00184; 00185; 00326-00329; 00352, (2022/02/06)
Provided are compounds that can find use as nitrosation reagents. Provided are nitrosation methods that include reacting a substrate with one of the provided nitrosation reagents and thereby generating a nitrosation product. Provided are kits including a nitrosation reagent. Provided are compositions wherein the nitrosation reagent is enriched in the 15N isotope.
S-nitrosothiol chemistry at the single-molecule level
Choi, Lai-Sheung,Bayley, Hagan
supporting information; experimental part, p. 7972 - 7976 (2012/08/29)
SNO patrol: S-Nitrosothiols (RSNO) are important molecules involved in cell signaling, which control physiological processes such as vasodilation and bronchodilation. By using the protein pore α-hemolysin as a nanoreactor, the biological chemistry of RSNO has been investigated at the single-molecule level (see scheme). Copyright
