790653-50-8Relevant academic research and scientific papers
Highly Enantioselective Iridium-Catalyzed Hydrogenation of Cyclic Enamides
Salomó, Ernest,Orgué, Sílvia,Riera, Antoni,Verdaguer, Xavier
, p. 7988 - 7992 (2016)
The MaxPHOX–Ir catalyst system provided the highest selectivity ever reported for the reduction of cyclic enamides derived from α- and β-tetralones. This result indicates that iridium catalysts are also proficient in reducing alkenes bearing metal-coordinating groups. In the present system, selectivity was pressure-dependent: In most cases, a decrease in the H2pressure to 3 bar resulted in an increase in enantioselectivity. Moreover, the process can be carried out in environmentally friendly solvents, such as methanol and ethyl acetate, with no loss of selectivity.
