790658-80-9Relevant academic research and scientific papers
DOPAMINE D2 RECEPTOR LIGANDS
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Page/Page column 130; 131; 132, (2016/07/05)
The present invention relates to novel dopamine D2 receptor ligands. The invention further relates to functionally-biased dopamine D2 receptor ligands and the use of these compounds for treating or preventing central nervous system and systemic disorders associated with dysregulation of dopaminergic activity.
Pd-catalyzed enantioselective C-H iodination: Asymmetric synthesis of chiral diarylmethylamines
Chu, Ling,Wang, Xiao-Chen,Moore, Curtis E.,Rheingold, Arnold L.,Yu, Jin-Quan
supporting information, p. 16344 - 16347 (2013/12/04)
An enantioselective C-H iodination reaction using a mono-N-benzoyl- protected amino acid has been developed for the synthesis of chiral diarylmethylamines. The reaction uses iodine as the sole oxidant and proceeds at ambient temperature and under air.
Design of Bronsted acid-assisted chiral Bronsted acid catalyst bearing a bis(triflyl)methyl group for a Mannich-type reaction
Hasegawa, Aiko,Naganawa, Yuki,Fushimi, Makoto,Ishihara, Kazuaki,Yamamoto, Hisashi
, p. 3175 - 3178 (2007/10/03)
A new Bronsted acid-assisted chiral Bronsted (chiral BBA) acid catalyst (1) was developed by substituting a hydroxy group of optically active 1,1′-bi(2-naphthol) with a stronger Bronsted acidic group such as a bis(trifluoromethanesulfonyl)methyl group. The enantioselective Mannich-type reaction of ketene silyl acetals with aldimines catalyzed by (R)-1 in the presence of stoichiometric achiral proton sources gave (S)-β-amino esters in high yield with moderate to good enantiomeric excesses.
