790659-90-4

Upstream product

• 616870-23-6 2-chloro-6-(4-methylphenyl)-5-phenylnicotinonitrile 

Downstream Products

• 791851-04-2 6-(4-{[4-(4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl]methyl}phenyl)-2-chloro-5-phenylnicotinonitrile 
• 791851-03-1 C₃₂H₂₇ClN₆ 
• 791851-01-9 C₃₂H₂₈ClN₅ 
• 616870-24-7 C₃₁H₂₆ClN₅O 
• 791851-00-8 C₂₉H₂₅ClN₈ 
• 791850-99-2 C₃₁H₂₅ClFN₅ 

Relevant academic research and scientific papers

Rapid assembly of diverse and potent allosteric Akt inhibitors

This paper describes the rapid assembly of four different classes of potent Akt inhibitors from a common intermediate. Among them, a pyridopyrimidine series displayed the best intrinsic and cell potency against Akt1 and Akt2. This series also showed a pro

INHIBITORS OF AKT ACTIVITY

The present invention is directed to compounds which contain substituted 5-deazapteridine moieties which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.