790661-29-9Relevant academic research and scientific papers
HCV NS5b RNA-dependent RNA polymerase inhibitors: From α,γ- diketoacids to 4,5-dihydroxypyrimidine- or 3-methyl-5- hydroxypyrimidinonecarboxylic acids. Design and synthesis
Summa, Vincenzo,Petrocchi, Alessia,Matassa, Victor G.,Taliani, Marina,Laufer, Ralph,De Francesco, Raffaele,Altamura, Sergio,Pace, Paola
, p. 5336 - 5339 (2004)
A new class of the HCV NS5b RNA-dependent RNA polymerase inhibitors, the dihyroxypyrimidinecarboxylic acid derivative, was designed from a diketoacid and meconic acid derivative discovered by screening. Mechanism of action and essential moieties required for activity were identified. The corresponding N-methylpyrimidinone was also prepared; both classes are novel, reversible, and selective inhibitors of the HCV NS5b polymerase with improved druglike characteristics.
