790691-46-2Relevant academic research and scientific papers
Synthesis and biological evaluation of novel N6-[4-(substituted) sulfonamidophenylcarbamoyl]adenosine-5′-uronamides as A3 adenosine receptor agonists
Baraldi, Pier Giovanni,Fruttarolo, Francesca,Tabrizi, Mojgan Aghazadeh,Romagnoli, Romeo,Preti, Delia,Bovero, Andrea,Pineda De Las Infantas, Maria Josè,Moorman, Allan,Varani, Katia,Borea, Pier Andrea
, p. 5535 - 5540 (2004)
A new series of 1-deoxy-1-[(6-(4-(substituted-aminosulfonyl)phenyl)amino) carbonylamino-9H-purin-9-yl]-N-ethyl-β-D-ribofuranuronamides (83-102) have been synthesized and tested at the human A3 adenosine receptor subtype. All the derivatives des
NOVEL ADENOSINE A3 RECEPTOR AGONISTS
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Page/Page column 42, (2008/06/13)
The invention realizes that a series of sulfonamido derivatives with a conserved uronamide group at the 5' position provide superior A3 receptor affinity as well as selectivity. These new adenosine agonists are sulfonamido deritatives N-substituted with aliphatic groups (cyclic or linear) or aromatic radicals.
