790696-96-7

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-3-methylpyridine-4-carboxaldehyde is used as a key intermediate for the synthesis of various pharmaceuticals. Its reactivity and functional groups enable the development of complex drug molecules with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Chloro-3-methylpyridine-4-carboxaldehyde serves as a crucial component in the preparation of agrochemicals. Its unique properties allow for the creation of compounds with pesticidal or herbicidal activities, contributing to crop protection and yield enhancement.
Used in Fine Chemicals Synthesis:
2-Chloro-3-methylpyridine-4-carboxaldehyde is utilized as a versatile building block in the synthesis of fine chemicals. Its presence in various chemical reactions facilitates the production of specialty chemicals used in a wide range of applications, from fragrances to dyes.
Used in Academic Research and Development:
2-Chloro-3-methylpyridine-4-carboxaldehyde is also employed in academic research and development settings. Its unique structure and reactivity make it an important subject for studying chemical reactions and exploring new synthetic pathways, ultimately contributing to the advancement of scientific knowledge in organic chemistry.

InChI:InChI=1/C7H6ClNO/c1-5-6(4-10)2-3-9-7(5)8/h2-4H,1H3

Upstream product

• 133928-64-0 2-chloro-3,N-dimethyl-N-phenyl-isonicotinamide 

Downstream Products

• 851314-24-4 8-{4-[3-(2-chloro-3,6-difluorophenoxy)propyl]phenyl}-5-aza-spiro[2.5]oct-7-ene-7-carboxylic acid cyclopropyl-[2-(2-hydroxypropoxy)-3-methylpyridin-4-ylmethyl]amide 

Relevant academic research and scientific papers

Design and preparation of potent, nonpeptidic, bioavailable renin inhibitors

Starting from known piperidine renin inhibitors, a new series of 3,9-diazabicyclo[3.3.1]nonene derivatives was rationally designed and prepared. Optimization of the positions 3, 6, and 7 of the diazabicyclonene template led to potent renin inhibitors. The substituents attached at the positions 6 and 7 were essential for the binding affinity of these compounds for renin. The introduction of a substituent attached at the position 3 did not modify the binding affinity but allowed the modulation of the ADME properties. Our efforts led to the discovery of compound (+)-26g that inhibits renin with an IC 50 of 0.20 nM in buffer and 19 nM in plasma. The pharmacokinetics properties of this and other similar compounds are discussed. Compound (+)-26g is well absorbed in rats and efficacious at 10 mg/kg in vivo.

BICYCLONONENE DERIVATIVES AS RENIN INHIBITORS

The invention relates to novel bicyclononene derivatives of Formula (I); and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.

BICYCLONONENE DERIVATIVES

The invention relates to novel bicyclononene derivatives and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.

DIAZABICYCLONONENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS

The invention relates to novel derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, p

DIAZABICYCLONONENE AND TETRAHYDROPYRIDINE DERIVATIVES AS RENIN INHIBITORS

The invention relates to novel bicyclic derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the com

DIAZABICYCLONONENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS

The invention relates to novel 3,9-diazabicyclo[3.3.1]nonene derivatives of formula (I), wherein Z is 0 or 1, one of m, n is 0 and the other is 1, and their use as inhibitors of renin.

DIAZABICYCLONONENE AND TETRAHYDROPYRIDINE DERIVATIVES WITH A NEW SIDE-CHAIN

The invention relates to novel bicyclic derivatives, and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the co

TETRAHYDROPYRIDINE DERIVATIVES

The invention relates to novel tetrahydropyridine derivatives and use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin. (I) wherein X and Y represent independently hydrogen, fluorine or a methyl group; X and Y do not represent both hydrogen at the same time or X and Y may together form a cyclopropyl ring; W represents a phenyl or a heteroaryl, the heteroaryl ring being a six-membered and non-fused ring, the phenyl ring and the heteroaryl are substituted with V in position 3 or 4; A and B independently represent-O-;-S-;-SO-or-SO2-; U represents aryl or heteroaryl; T represents-CONR1-;-(CH2)pOCO-;-(CH2)pN(R1)CO-;-(CH2)p N(R1)SO2-;-COO-;-(CH2)pOCONR1-or-(CH2)pN(R2)CONR1-; R1 and R2 independently respresent hydrogen; lower alkyl; lower alkenyl; lower alkynil; cycloalkyl; aryl-lower alkyl, heteroaryl-lower alkyl or cycloalkyl-lower alkyl; Q represents lower alkylene or lower alkenylene; M represents hydrogen; cycloalkyl; aryl; heterocyclyl or heteroaryl: