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2-[2-(methylamino)ethyl]-5-nitro-1H-benzo[de]isoquinoline-1,3(2H)-dione is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

79070-62-5

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79070-62-5 Usage

Type

Synthetic chemical compound

Core structure

Benzo[de]isoquinoline

Functional groups

Nitro group, methylaminoethyl side chain

Potential medicinal properties

Yes

Biological activity

Central nervous system

Studied for potential treatment of

Parkinson's disease, schizophrenia

Additional potential properties

Cytotoxic, anti-cancer

Interest for drug development

Anti-tumor

Mechanisms of action

Under investigation

Potential uses

Under investigation

Research status

Further research needed to understand pharmaceutical potential

Check Digit Verification of cas no

The CAS Registry Mumber 79070-62-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,9,0,7 and 0 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 79070-62:
(7*7)+(6*9)+(5*0)+(4*7)+(3*0)+(2*6)+(1*2)=145
145 % 10 = 5
So 79070-62-5 is a valid CAS Registry Number.

79070-62-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[2-(methylamino)ethyl]-5-nitrobenzo[de]isoquinoline-1,3-dione

1.2 Other means of identification

Product number -
Other names 2-(2-methylaminoethyl)-5-nitrobenz(de)isoquinoline-1,3-dione

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:79070-62-5 SDS

79070-62-5Downstream Products

79070-62-5Relevant academic research and scientific papers

Design, synthesis and biological evaluation of 3-nitro-1,8-naphthalimides as potential antitumor agents

Liang, Gui-Bin,Ma, Xian-Li,Su, Dan,Wei, Jian-Hua,Xin, Mao,Yang, Chen-Hui,Zhang, Ye

, (2020/03/03)

A series of 3-nitro-naphthalimides 1(1a–1h) were designed and synthesized as antitumor agents. MTT assay results showed that all these compounds exhibited obvious antiproliferative activity against SKOV3, HepG2, A549, T-24 and SMMC-7721 cancer cell lines, while compound 1a displayed the best antiproliferative activity against HepG2 and T-24 cell lines in comparison with mitonafide, with IC50 of 9.2 ± 1.8 and 4.133 ± 0.9 μM, respectively. In vivo antiproliferative activity assay results showed that compound 1a exhibited good antiproliferative activity in the HepG2 and T-24 models, compared with mitonafide. Action mechanism results showed that compound 1a could induced the damage of DNA and the inhibition topo I, accompanying by inducing the G2-stage arresting and the apoptosis of T-24 cancer cells through up-regulating expression levels of cyclin B1, cdc 2-pTy, Wee1, γH2AX, p21, Bax and cytochrome c and down-regulating expression of Bcl-2.

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