790702-57-7 Usage
Uses
Used in Pharmaceutical Industry:
5-(dimethylsulfamoyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-(pyrrolidin-1-yl)benzamide is used as an inhibitor of oligosaccharyltransferase (OST) for its ability to selectively arrest proliferation in cells dependent on EGFR for survival.
Used in Antiviral Applications:
5-(dimethylsulfamoyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-(pyrrolidin-1-yl)benzamide is used as an antiviral agent for its ability to display antiviral behavior against various flaviviruses, including Dengue, West Nile, Yellow fever, and Zika.
Used in Cancer Treatment:
5-(dimethylsulfamoyl)-N-(5-methyl-1,3-thiazol-2-yl)-2-(pyrrolidin-1-yl)benzamide is used as a chemosensitizer and radiosensitizer for its ability to overcome resistance to EGFR tyrosine kinase inhibitors in mutant NSCLC cells and enhance the radiosensitivity and cytotoxic effects of chemotherapy in glioma cells with high levels of RTK activation.
References
1) Lopez-Sambrooks et al. (2016), Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells; Nature Chem. Biol. 12 1023
2) Puschnik et al. (2017), A small molecule oligosaccharyltransferase inhibitor with pan-flaviviral activity; Cell Rep. 21 3032
3) Lopez-Sambrooks et al. (2018), Oligosaccharyltransferase Inhibition Overcomes Therapeutic Resistance to EGFR Tyrosine Kinase Inhibitors; Cancer Res. July 19, 2018 Epub ahead of print
4) Baro et al. (2018), Oligosaccharyltransferase Inhibition Reduces Receptor Tyrosine Kinase Activation and Enhances Glioma Radiosensitivity; Clin. Cancer Res. July 2, 2018 Epub ahead of print
Check Digit Verification of cas no
The CAS Registry Mumber 790702-57-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,9,0,7,0 and 2 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 790702-57:
(8*7)+(7*9)+(6*0)+(5*7)+(4*0)+(3*2)+(2*5)+(1*7)=177
177 % 10 = 7
So 790702-57-7 is a valid CAS Registry Number.
790702-57-7Relevant academic research and scientific papers
N-LINKED GLYCOSYLATION INHIBITORS AND METHODS OF USING SAME
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, (2022/03/22)
The present disclosure includes compounds, compositions, and methods for preventing or treating diseases associated with N-linked glycosylation and/or oligosaccharyltransferase function in a subject in need thereof. The methods comprise administering to the subject an effective amount of at least one compound and/or pharmaceutical composition of the disclosure.
INHIBITORS OF N-LINKED GLYCOSYLATION AND METHODS USING SAME
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Page/Page column 63-64, (2017/02/24)
The present invention includes novel compounds and methods for preventing or treating diseases associated with N-linked glycosylation in a subject in need thereof. The methods comprise administering to the subject an effective amount of at least one compo
