790710-83-7Relevant academic research and scientific papers
NOVEL AMINATION PROCESS
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Page/Page column 24, (2008/06/13)
Provided herein are novel processes for the preparation of intermediates that may be useful in the preparation of 5-Ht1b receptor antagonist useful in the treatment of depression, anxiety and other related diseases. The present processes may of
Successful development and scale-up of a palladium-catalysed amination process in the manufacture of ZM549865
Robinson, Graham E.,Cunningham, Oliver R.,Dekhane, Mouloud,McManus, Julie C.,O'Kearney-McMullan, Anne,Mirajkar, Abdurrazzaque M.,Mishra, Vikas,Norton, Alison K.,Venugopalan,Williams, Emyr G.
, p. 925 - 930 (2013/09/03)
Key steps in the synthesis of ZM549865 (a 5-HT receptor antagonist) are the palladium-catalysed amination of ethyl 8-bromo-6-fluoro-4-oxo-4H-2- chromenecarboxylate and subsequent hydrolysis of the ester group. The development of a simple, robust process c
