79074-64-9

Upstream product

• 13373-10-9 4-amino-2,4-dihydro-5-(phenylmethyl)-3H-1,2,4-triazole-3-thione 
• 532-27-4 1-chloroacetophenone 
• 70-11-1 α-bromoacetophenone 
• 13373-10-9 5-Benzyl-4-amino-3-mercapto-1,2,4-triazole 

Downstream Products

• 1083071-80-0 1-acetyl-3-benzyl-7-acetylsulfanyl-6-phenyl-1H-pyrazolo[5,1-c][1,2,4]triazole 

Relevant academic research and scientific papers

Pyrolytic desulfurization ring contraction of condensed thiadiazines as a general route towards pyrazoloazines and pyrazoloazoles with a bridgehead (ring junction) nitrogen atom

Pyrolytic conversion of [1,2,4]triazino[3,4-b][1,3,4]thiadiazin-4-ones, [1,3,4]thiadiazino[2,3-b]quinazolin-10-ones and [1,2,4]triazolo[3,4-b][1,3,4]thiadiazines into their corresponding pyrazolo[5,1-c][1,2,4]triazin-4-ones, pyrazolo[4,3-b]quinazolin-9-on

Synthesis of Heterocycles. Part VII . Synthesis and Antimicrobial Activity of Some 7H-s-Triazolothiadiazine and s-Triazolothiadiazole Derivatives

The cyclization of 4-amino-5-aryl-3-cyanomethylthio-1,2,4-triazoles II in the presence of concentrated sulfuric acid yields 7H-6-amino-s-triazolothiadiazines III.Cyclization of 4-amino-5-aryl-1,2,4-triazole-3-thiones I with phenacyl chloride yields 7H-3-aryl-6-phenyl-s-triazolothiadiazines IV.Similarly, compounds I condensed with cyanogen bromide, phenyl isothiocyanate and carbon disulfide to give the corresponding cyclized products 6-amino-3-aryl-s-triazolothiadiazoles V, 3-aryl-6-phenylamino-s-triazolothiadiazoles VI and 3-aryl-s-triazolothiadiazol-6(5H)thiones VII, respectively.Also in the presence of phosphoryl chloride, compounds I underwent cyclization with monocarboxylic acids and oxalic acid to 3,6-diaryl-s-triazolothiadiazole VIII and 6,6'-bis(3-aryl-s-triazolothiadiazoles) IX.The above compounds were screened for their antimicrobial activity.

Bridgehead Nitrogen Heterocycles : Novel Reactions of 5-Aryl-4-amino-3-mercapto-4H-1,2,4-triazoles

The reactions of 5-aryl-4-amino-3-mercapto-4H-1,2,4-triazoles (I, R=C6H5, o-ClC6H4, C6H5CH2-) with phenacyl bromide, dimedone, benzoin, chloroacetyl chloride, carbon disulphide and tetracyclone furnish the condensed products whose structures have been ass