79082-05-6

Usage

Uses

Used in Pharmaceutical Industry:
Gusanlung B is used as an anti-inflammatory agent for its ability to inhibit the production of pro-inflammatory cytokines and enzymes, reducing inflammation and oxidative stress in the body.
Used in Neuroprotective Applications:
Gusanlung B is used as a neuroprotective agent for its potential in treating neurodegenerative disorders, due to its ability to protect against oxidative damage and inflammation in the brain.
Used in Traditional Chinese Medicine:
Gusanlung B is used as a natural remedy for alleviating inflammation and protecting against oxidative damage in the body, based on its traditional use and therapeutic properties.

InChI:InChI=1/C20H19NO5/c1-23-15-4-3-12-7-14-13-9-17-16(25-10-26-17)8-11(13)5-6-21(14)20(22)18(12)19(15)24-2/h3-4,8-9,14H,5-7,10H2,1-2H3/t14-/m0/s1

Upstream product

• 79027-72-8 (+)-cis-2,3-(Methylenedioxy)-8-oxo-9,10-dimethoxy-13-carboxytetrahydroprotoberberine 
• 68408-57-1 (+/-)-cis-2,3-(Methylenedioxy)-8-oxo-9,10-dimethoxy-13-carboxytetrahydroprotoberberine 

Relevant academic research and scientific papers

The absolute configuration of (+)-thalictricavine

(+)-Thalictricavine (7) and (+)-canadine (1) have been synthesized from an optically resolved (+)-13-carboxy-7,8,13,14-tetrahydro-8-oxoprotoberberine 15.This establishes tha absolute configuration of (+)-thalictricavine (7) as 13S, 14R

Absolute Configurations of the cis- and trans-13-Methyltetrahydroprotoberberines. Total Synthesis of (+)-Thalictricavine, (+)-Canadine, (+/-)-, (-)-, and (+)-Thalictrifoline, and (+/-)-, (-)-, and (+)-Cavidine

The tetrahydroprotoberberine alkaloids (+)-thalictricavine and (+)-canadine have been synthesized from an optically resolved (+)-13-carboxy-7,8,13,14-tetrahydro-9-oxoprotoberberine .This establishes the absolute configuration of (+)-thalictricavine as 13S,14R. (+)-Thalictrifoline and (+)-cavidine have also been prepared from a common intermediate, (+)-32, whose absolute configuration was established by correlation with (+)-26.This determines the absolute configuration of (+)-thalictrifoline as 13R,14R, of (+)-corydalic acid methyl ester (22) as 3R,4R, and of the protopine (+)-corycavine (20) as 13R.