79082-62-5Relevant academic research and scientific papers
Stereoselectivity and substrate specificity in the kinetic resolution of methyl-substituted 1-oxaspiro[2.5]octanes by Rhodotorula glutinis epoxide hydrolase
Weijers, Carel A. G. M.,Meeuwse, Petra,Herpers, Robert L. J. M.,Franssen, Maurice C. R.,Sudhoelter, Ernst J. R.
, p. 6639 - 6646 (2007/10/03)
The kinetic resolution of a range of methyl-substituted 1-oxaspiro[2.5]octanes by yeast epoxide hydrolase (YEH) from Rhodotorula glutinis has been investigated. The structural determinants of substrate specificity and stereoselectivity of YEH toward these
Reexamination of diisobutylaluminum hydride as a stereoselective reducing agent for reduction of cyclic ketones to thermodynamically more stable alcohols
Cha, Jin Soon,Kwon, Oh Oun,Kim, Jong Mi,Cho, Sung Dong
, p. 1465 - 1466 (2007/10/03)
The reducing property of diisobutylaluminum hydride (DIBAH) has been reexamined as a stereoselective reducing agent for reduction of representative cyclic ketones. When the reduction of excess cyclic ketone with DIBAH was carried out at 0°C in ethyl ether, only 1 equiv of the free hydride was involved to show a low stereoselectivity. However, when performed at 25°C or under reflux in ethyl ether, one isobutyl group as well as the free hydride was also involved in this reduction: the first equiv of ketone was reduced rapidly and the second one reduced, in a relatively slow rate. In addition, the stereoselectivity increases consistently with increase of reaction time to afford the thermodynamically more stable isomer alcohols exclusively.
