79083-85-5

Upstream product

• 15761-38-3 L-N-Boc-Ala 
• 72086-77-2 (tert-butyloxycarbonyl)-L-alanyl-α-aminoisobutyric acid methyl ester 
• 72086-86-3 N-tert-butyloxycarbonyl-S-alanyl-α-aminoisobutyryl-S-alanine methyl ester 
• 72086-94-3 Boc-L-Ala-Aib-Ala-Aib-Ala-OMe 
• 72086-87-4 S-alanyl-α-aminoisobutyryl-S-alanine methyl ester hydrochloride 
• 72095-04-6 Boc-Ala-Aib-OH 
• 70134-38-2 Boc-L-Ala-Aib-Ala-Aib-Ala-OH 
• 82954-83-4 H-L-Glu(OBzl)-L-Ala-Aib-Ala-Aib-Ala-OMe*CF₃COOH 

Relevant academic research and scientific papers

The α-Helical Conformation of the Undecapeptide Boc-L-Ala-2-Glu(OBzl)-Ala-2-OMe: Synthesis, X-Ray Crystal Structure, and Conformation in Solution

As models of the helical N-terminal part of alamethicin the undecapeptides Boc-L-Ala-2-Glu(OBzl)-Ala-2-OMe (1) and Boc-L-Ala-2-Gly-Ala-2-OMe (2) were synthesized. 1 was examined by X-ray crystallography using direct methods for solution of the phase problem.The unit cell (P21) contains two antiparallel α-helices with nine residues being part of the helix.Continuing chains of head-to-tail linked α-helices are arranged in the crystal lattice.CD and 13C NMR spectra revealed a pronounced stabilizing effect of the α-aminoisobutyric acid residues for the α-helical conformation in solution.