79091-24-0Relevant academic research and scientific papers
HETEROARYL-SUBSTITUTED PYRAZOLO-PYRIDINE PROTEIN KINASE INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH
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Page/Page column 48, (2021/02/05)
The invention relates to pyrazolo-pyridine compounds which inhibit mitogen-activated protein kinase kinase 4 (MKK4) and in particular, selectively inhibit MKK4 over protein kinases JNK1 and MKK7. The compounds are useful for promoting liver regeneration or reducing or preventing hepatocyte death. They are further useful for treating osteoarthritis or rheumatoid arthritis, or CNS-related diseases.
THE SYNTHESIS AND AMINOLYSIS OF SOME 4-CHLORO-2-(SUBSTITUTED)THIOPYRIMIDINES
Hurst, Derek, T.,Johnson, Matthew
, p. 611 - 616 (2007/10/02)
Some 2-methylthio,2-methylsulphinyl and 2-methylsulphonyl-4-chloropyrimidines have been prepared.In each case which was studied except one the chloride ion was that which was preferentially displaced by diethylamine.The pseudo first order rate constant of for each reaction was determined the results showing that oxidation of the 2-methylthio group greatly enhances the rate of displacement of the 4-chloro group.
Reactions of Benzothiohydrazide as a Bidentate Nucleophile
Elliott, Arthur J.
, p. 799 - 800 (2007/10/02)
Benzothiohydrazide acts as a 1,4-bidentate nucleophile under basic conditions, and condenses with suitably substituted pyridines, pyrimidines and quinoxalines to yield ring-fused-1,3,4-thiadiazines unsubstituted on the 4-nitrogen position.
