79091-96-6Relevant academic research and scientific papers
Development of a scalable synthesis of a pyridinyl-3-azabicyclononene, a novel nicotinic partial agonist
Breining, Scott R.,Genus, John F,Mitchener, J. Pike,Cuthbertson, Timothy J,Heemstra, Ronald,Melvin, Matt S,Dull, Gary M,Yohannes, Daniel
, p. 413 - 421 (2013/06/05)
The process research and development of two syntheses of a novel nicotinic partial agonist, TC-8817 ((+)-5), are described. The original Medicinal Chemistry route had multiple flaws, making it unsuitable for further development. A second approach was expl
A short enantioselective pathway for the synthesis of the anti-influenza neuramidase inhibitor oseltamivir from 1,3-butadiene and acrylic acid
Yeung, Ying-Yeung,Hong, Sungwoo,Corey
, p. 6310 - 6311 (2007/10/03)
A short synthetic pathway has been developed for the synthesis of oseltamivir (1) or the enantiomer (ent-1). The intermediates and conditions for this process are summarized in Scheme 1. The synthesis provides a number of advantages: (1) use of inexpensiv
Conformational Analysis by Thermal Variation of Rotatory Power. Monosubstituted Cyclohexene Enantiomers
Lauricella, Robert,Kechayan, Josette,Bodot, Hubert
, p. 1577 - 1582 (2007/10/02)
The conformer rotatory powers of six 4-substituted cyclohexenes have been calculated by extension of the Brewster procedure and used to estimate the conformational free energy differences.The corresponding conformational rotivities are utilized to analyze
