79098-62-7

Upstream product

• 40064-34-4 4-piperidone monohydrochloride monohydrate 
• 1835-02-5 2-Bromo-1-(3,4-dimethoxyphenyl)ethanone 
• 59-48-3 2-oxoindole 
• 79099-08-4 3-<1-(t-butyloxycarbonyl)-4-piperidylidene>-1,3-dihydro-2H-indol-2-one 
• 79098-55-8 3-<1-<2-(3,4-dimethoxyphenyl)-2-oxoethyl>-4-piperidylidene>-1,3-dihydro-2H-indol-2-one 
• 40064-34-4 piperidine-4,4-diol hydrochloride 
• 79099-09-5 3-(4-piperidylidene)-1,3-dihydro-2H-indol-2-one 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 

Relevant academic research and scientific papers

Synthesis of 3-(4-Piperidylidene)-1,3-dihydro-2H-indol-2-one Derivatives

3--1,3-dihydro-2H-indol-2-one with structure II, as potential antihypertensive agent was synthesized.The intermediates, 3--1,3-dihydro-2H-indol-2-one (5) were prepared from 4-piperidone via 4 steps.Selective reduction of carbonyl group in 5 was realized using diisobutyl aluminium hydride to afford compound II.

New antihypertensive agents. III. Synthesis and antihypertensive activity of some arylalkyl piperidines carrying a heterocycle at the 4-position

We synthesized a series of arylalkyl piperidines (II) carrying a heterocycle at the 4-position of piperidine and examined the hypotensive activities of the products. Compound 23 had the highest hypotensive activity in anesthetized normotensive rats (-78mmHg, 30 mg/kg, i.p.) and compound 12 showed the strongest hypotensive activity (-95 mmHg, 30 mg/kg, p.o.) in unanesthetized spontaneously hypertensive rats. Only compound 16 produced a considerable decrease in blood pressure in both animal models.