79098-87-6

Basic information

• Product Name: 1-benzyl-4-(2-nitrophenylmethyl)aminopiperidine*2HCl
• Synonyms: 1-benzyl-4-(2-nitrophenylmethyl)aminopiperidine*2HCl
• CAS NO: 79098-87-6
• Molecular Weight: 398.332
• Mol File: 79098-87-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-benzyl-4-(2-nitrophenylmethyl)aminopiperidine*2HCl(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-4-(2-nitrophenylmethyl)aminopiperidine*2HCl(79098-87-6)
• EPA Substance Registry System: 1-benzyl-4-(2-nitrophenylmethyl)aminopiperidine*2HCl(79098-87-6)

Safety Data

• Hazardous Substances Data: 79098-87-6(Hazardous Substances Data)

Upstream product

• 1205-72-7 1-benzyl-4-amino-piperidine dihydrochloride 
• 552-89-6 2-nitro-benzaldehyde 

Downstream Products

• 79122-21-7 threo-1-<2-hydroxy-2-(3,4-dimethoxyphenyl)-1-methylethyl>-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl)piperidine 
• 79122-21-7 erythro-1-<2-hydroxy-2-(3,4-dimethoxyphenyl)-1-methylethyl>-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl)piperidine 
• 79106-29-9 1-[2-(3,4-Dimethoxyphenyl)-2-hydroxyethyl]-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine 
• 79106-31-3 1-<2-oxo-2-(3,4-dimethoxyphenyl)-1-methylethyl>-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl)piperidine 
• 79106-47-1 1-[2-(3,4-Dichlorophenyl)-2-hydroxyethyl]-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine 
• 79106-27-7 1-(3,4-dimethoxybenzoylmethyl)-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine 
• 79106-46-0 1-[2-(4-Methoxyphenyl)-2-hydroxyethyl]-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine 
• 79106-45-9 1-<2-(4-chlorophenyl)-2-hydroxyethyl>-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl)piperidine 
• 79106-44-8 1-[2-(3-Chlorophenyl)-2-hydroxyethyl]-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine 
• 79098-78-5 1-(3,4-dichlorobenzoylmethyl)-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine 
• 79106-42-6 1-(4-Methoxybenzoylmethyl)-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine 
• 85350-65-8 1-(3-phenyl-3-hydroxypropyl)-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl)piperidine 
• 79106-41-5 1-<2-oxo-2-(4-chlorophenyl)ethyl>-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl)piperidine 
• 79106-40-4 1-(3-Chlorobenzoylmethyl)-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidin 

Relevant articles and documents

Synthesis of 1- and 3-(1-substituted 4-piperidinyl)-1,2,3,4-tetrahydro-2-oxoquinazolines as potential antihypertensive agents

A series of 1- and 3-(1-substituted 4-piperidinyl)-1,2,3,4-tetrahydro-2-oxoquinazolines were synthesized and tested for antihypertensive activity. Among the compounds tested, 1-(2-hydroxy-2-phenethyl)-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl) piperidine derivatives were generally the most effective in lowering blood pressure in the spontaneous hypertensive rat model. Of these, 1-[2-(4-chlorophenyl)-2-hydroxyethyl]-4-(1,2,3,4-tetrahydro-2-oxo-3- quinazolinyl)piperidine (KF5908) seemed the most promising.

Piperidine derivatives and pharmaceutical compositions containing same

A new piperidine derivative represented by the formula: STR1 wherein X is oxygen, sulfur, carbonyl, hydroxymethylene or methylene; R is straight-chain alkylene having 1-4 carbon atoms with or without lower alkyl substituent(s); m and n are 0 or 1, and are