791040-02-3Relevant academic research and scientific papers
Multikilogram synthesis of a hepatoselective glucokinase activator
Dunetz, Joshua R.,Berliner, Martin A.,Xiang, Yanqiao,Houck, Timothy L.,Salingue, Fabrice H.,Chao, Wang,Yuandong, Chen,Shenghua, Wang,Huang, Yun,Farrand, Douglas,Boucher, Steven J.,Damon, David B.,Makowski, Teresa W.,Barrila, Mark T.,Chen, Raymond,Martinez, Isamir
, p. 1635 - 1645 (2012)
This work describes the process development and manufacture of early-stage clinical supplies of a hepatoselective glucokinase activator, a potential therapy for type 2 diabetes mellitus. Critical issues centered on challenges associated with the synthesis
